(Z)-3-(2-hydroxy-2-methylpropylidene)-3H-isobenzofuran-1-one

Base Information

• Chemical Name: (Z)-3-(2-hydroxy-2-methylpropylidene)-3H-isobenzofuran-1-one
• CAS No.: 147454-71-5
• Molecular Formula: C₁₂H₁₂O₃
• Molecular Weight: 204.225
• Mol file: 147454-71-5.mol

Synonyms:(Z)-3-(2-hydroxy-2-methylpropylidene)-3H-isobenzofuran-1-one

Chemical Property of (Z)-3-(2-hydroxy-2-methylpropylidene)-3H-isobenzofuran-1-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (Z)-3-(2-hydroxy-2-methylpropylidene)-3H-isobenzofuran-1-one

There total 2 articles about (Z)-3-(2-hydroxy-2-methylpropylidene)-3H-isobenzofuran-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Iodobenzoic acid (88-67-5) → 2-(3-Hydroxy-3-methyl-but-1-ynyl)-benzoic acid (147454-79-3) + (Z)-3-(2-hydroxy-2-methylpropylidene)-3H-isobenzofuran-1-one (147454-71-5) + 2-methyl-but-3-yn-2-ol (115-19-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) DMF, 1 h, 2.) DMF, a) RT, 1 h, b) 30 deg C, 6 h;

DOI:10.1039/c39930000086

Reference yield:

2-Iodobenzoic acid (88-67-5) + 2-methyl-but-3-yn-2-ol (115-19-5) → 2-(3-Hydroxy-3-methyl-but-1-ynyl)-benzoic acid (147454-79-3) + 3-(1-hydroxy-1-methylethyl)-isochromen-1-one + (Z)-3-(2-hydroxy-2-methylpropylidene)-3H-isobenzofuran-1-one (147454-71-5)

Guidance literature:

With tetrabutyl-ammonium chloride; potassium acetate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; at 30 ℃; for 6h; other catalyst, base, solvents, temperature and time;

DOI:10.1039/a705450e

upstream raw materials:

2-Iodobenzoic acid

2-methyl-but-3-yn-2-ol