7-O-acyl-2-(t-butyldimethylsilyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan

Base Information

• Chemical Name: 7-O-acyl-2-(t-butyldimethylsilyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan
• CAS No.: 905752-39-8
• Molecular Formula: C₂₇H₃₄O₈Si
• Molecular Weight: 514.648
• Mol file: 905752-39-8.mol

Synonyms:7-O-acyl-2-(t-butyldimethylsilyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan

Chemical Property of 7-O-acyl-2-(t-butyldimethylsilyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-O-acyl-2-(t-butyldimethylsilyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan

There total 7 articles about 7-O-acyl-2-(t-butyldimethylsilyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H32O7Si (1007198-30-2) + acetic anhydride (108-24-7) → 7-O-acyl-2-(t-butyldimethylsilyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan (905752-39-8)

Guidance literature:

With pyridine; at 20 ℃; for 2h;

Reference yield:

2-t-butyldimethylsilyl-7-isopropoxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan (905752-33-2) → 7-O-acyl-2-(t-butyldimethylsilyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan (905752-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane

2: pyridine

With pyridine; aluminum (III) chloride; In dichloromethane;

DOI:10.1021/jm200454y

Reference yield:

5-iodo-1,2,3-trimethoxybenzene (25245-29-8) → 7-O-acyl-2-(t-butyldimethylsilyl)-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan (905752-39-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.67 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -60 - 0 °C

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 16 h / 20 °C

3.1: aluminum (III) chloride / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

4.1: pyridine / 2 h / 20 °C

With pyridine; aluminum (III) chloride; n-butyllithium; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; cyclohexane;

upstream raw materials:

C₂₅H₃₂O₇Si

acetic anhydride

5-iodo-1,2,3-trimethoxybenzene

2-t-butyldimethylsilyl-3-formyl-6-methoxy-7-isopropoxybenzofuran

Downstream raw materials:

7-O-acyl-2-bromo-6-methoxy-3-(3,4,5-trimethoxybenzoyl)-benzo[b]furan

dibenzyl 6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzofuran-7-yl phosphate

2-methyl-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan

2-cyano-7-hydroxy-6-methoxy-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan