N-(2-((4-(methoxymethyl)thiazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

Base Information

Chemical Name:N-(2-((4-(methoxymethyl)thiazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide
CAS No.:1381778-51-3
Molecular Formula:C₁₈H₁₆N₆O₃S
Molecular Weight:396.429
Hs Code.:

Synonyms:N-(2-((4-(methoxymethyl)thiazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

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Chemical Property of N-(2-((4-(methoxymethyl)thiazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

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Technology Process of N-(2-((4-(methoxymethyl)thiazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

There total 4 articles about N-(2-((4-(methoxymethyl)thiazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1381778-67-1
2-((4-(methoxymethyl)thiazol-2-yl)methyl)-2H-1,2,3-triazol-4-amine

: 99924-18-2
5-phenyl-1,3-oxazole-4-carboxylic acid

: 1381778-51-3
N-(2-((4-(methoxymethyl)thiazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

Guidance literature:: 5-phenyl-1,3-oxazole-4-carboxylic acid; With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

2-((4-(methoxymethyl)thiazol-2-yl)methyl)-2H-1,2,3-triazol-4-amine; In dichloromethane; at 20 ℃;

Reference yield:

: 321371-29-3
2-chloromethyl-1,3-thiazole-4-carboxylic acid methyl ester

: 1381778-51-3
N-(2-((4-(methoxymethyl)thiazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.2: 1 h / 20 °C

3.1: silver(l) oxide / dichloromethane / 40 °C / Inert atmosphere; Darkness

4.1: ammonium chloride; iron / ethanol; water / 0.42 h / 75 °C / Inert atmosphere

5.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

5.2: 20 °C

With dmap; iron; diisobutylaluminium hydride; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1381778-65-9
(2-((4-nitro-2H-1,2,3-triazol-2-yl)methyl)thiazol-4-yl)methanol

: 1381778-51-3
N-(2-((4-(methoxymethyl)thiazol-2-yl)methyl)-2H-1,2,3-triazol-4-yl)-5-phenyloxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: silver(l) oxide / dichloromethane / 40 °C / Inert atmosphere; Darkness

2.1: ammonium chloride; iron / ethanol; water / 0.42 h / 75 °C / Inert atmosphere

3.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

3.2: 20 °C

With dmap; iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In ethanol; dichloromethane; water;