13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

Base Information

• Chemical Name: 13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one
• CAS No.: 190278-37-6
• Molecular Formula: C₂₉H₂₃NO₆
• Molecular Weight: 481.505
• Mol file: 190278-37-6.mol

Synonyms:13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

Chemical Property of 13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

There total 7 articles about 13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

3-nitrocoumarin (28448-04-6) + Papaverine (58-74-2) → 13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one (190278-37-6)

Guidance literature:

With sodium hydrogencarbonate; In 5,5-dimethyl-1,3-cyclohexadiene; at 160 ℃; for 16h; Reagent/catalyst; Temperature; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.joc.7b01061

Reference yield: 14.0%

Papaverine (58-74-2) + 4-chloro-3-nitro-chromen-2-one (38464-20-9) → 13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one (190278-37-6)

Guidance literature:

With ytterbium(III) triflate; In 5,5-dimethyl-1,3-cyclohexadiene; at 130 ℃; for 48h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.5b03524

Reference yield:

1-[1-(3,4-Dimethoxy-phenyl)-2-(2-hydroxy-phenyl)-2-oxo-ethyl]-2-ethoxycarbonylmethyl-6,7-dimethoxy-isoquinolinium; bromide → 13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one (190278-37-6)

Guidance literature:

With triethylamine; In chloroform; Yield given; 1.) room temp., 1.5 d, 2.) reflux, 30 min;

DOI:10.1016/S0040-4020(97)00287-1

upstream raw materials:

methyl salicylate

Papaverine

4-chloro-3-nitro-chromen-2-one

3-nitrocoumarin