28448-04-6

Basic information

• Product Name: 2H-1-Benzopyran-2-one, 3-nitro-
• Synonyms: 3-nitro-chromen-2-one;HMS545H12;3-nitro-2H-chromen-2-one;3-nitrocoumarin
• CAS NO: 28448-04-6
• Molecular Formula: C9H5NO4
• Molecular Weight: 191.143
• Mol File: 28448-04-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2H-1-Benzopyran-2-one, 3-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-2-one, 3-nitro-(28448-04-6)
• EPA Substance Registry System: 2H-1-Benzopyran-2-one, 3-nitro-(28448-04-6)

Safety Data

• Hazardous Substances Data: 28448-04-6(Hazardous Substances Data)

Upstream product

• 1173429-43-0 N-methyl-N-[4-(methylsulfanyl)-3-nitro-4H-chromen-2-yl]amine 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1635-31-0 aminocoumarine 
• 111586-44-8 2-methoxy-N-(2-oxo-2H-chromen-3-yl)benzamide 
• 190278-37-6 13-(3,4-Dimethoxy-phenyl)-10,11-dimethoxy-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one 

Relevant articles and documents

Copper-catalyzed C(sp3)-C(sp2) cross-coupling: Synthesis of 4-aryl-2-alkylamino-3-nitro-4h-chromenes

Inexpensive copper(II) acetate effectively catalyzes cross-coupling of electron-deficient as well as electron-rich arylboronic acids with 4-methylsulfanyl-2-alkylamino-3-nitro-4H-chromenes under near neutral conditions at room temp. to furnish a range of 4-aryl-4H-chromenes. This new strategy enabled substitution of the C(4)SMe group present on a sp3 hybridized carbon of the 4H-chromenes with aryl/heteroaryl groups. Mechanistic probing revealed that the CuI-CuIII cycle is involved in catalysis. One-pot sequential substitution of C(4)SMe followed by C(6)Br with aryl groups has been achieved through Cu(OAc)2 and Pd 2(dba)3 (Suzuki coupling) catalysis. Copyright