(S)-3-[(Benzyl-methyl-amino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (S)-3-[(Benzyl-methyl-amino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS No.: 177947-77-2
• Molecular Formula: C₁₈H₂₈N₂O₂
• Molecular Weight: 304.433
• Mol file: 177947-77-2.mol

Synonyms:(S)-3-[(Benzyl-methyl-amino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property of (S)-3-[(Benzyl-methyl-amino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-[(Benzyl-methyl-amino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 4 articles about (S)-3-[(Benzyl-methyl-amino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R)-1-[(R)-1-phenylethyl]-3-(hydroxymethyl)pyrrolidine (99735-47-4) → (S)-3-[(Benzyl-methyl-amino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (177947-77-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pearlmans catalyst / methanol; H₂O / 2 h / 2068.59 Torr

2: 100 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

3: toluene / 18 h / Heating

With hydrogen; triethylamine; palladium hydroxide - carbon; In methanol; dichloromethane; water; toluene;

DOI:10.1021/jm9805687

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (S)-3-[(Benzyl-methyl-amino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (177947-77-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pearlmans catalyst / methanol; H₂O / 2 h / 2068.59 Torr

2: 100 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

3: toluene / 18 h / Heating

With hydrogen; triethylamine; palladium hydroxide - carbon; In methanol; dichloromethane; water; toluene;

DOI:10.1021/jm9805687

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (S)-3-[(Benzyl-methyl-amino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (177947-77-2)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd(OH)2 / methanol; H₂O

2: Et₃N / CH₂Cl₂

3: toluene / 90 °C

With hydrogen; triethylamine; palladium dihydroxide; In methanol; dichloromethane; water; toluene;

DOI:10.1021/jm9704558

upstream raw materials:

benzyl-methyl-amine

(3R)-1-(tert-butoxycarbonyl)-3-[(methane-sulfonyloxy)methyl]pyrrolidine

di-tert-butyl dicarbonate

(3R)-1-[(R)-1-phenylethyl]-3-(hydroxymethyl)pyrrolidine

Downstream raw materials:

Benzyl-methyl-(R)-pyrrolidin-3-yl-amine

Benzyl-methyl-(R)-1-pyrrolidin-3-ylmethyl-amine