99735-47-4

Usage

Uses

Used in Pharmaceutical Industry:
3-Pyrrolidinemethanol, 1-[(1R)-1-phenylethyl]-, (3R)is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of effective medications. Its chiral nature allows for the creation of enantiomerically pure compounds, which is crucial for ensuring the desired therapeutic effects and minimizing potential side effects.
Used in Organic Synthesis:
In the field of organic synthesis, 3-Pyrrolidinemethanol, 1-[(1R)-1-phenylethyl]-, (3R)serves as a versatile building block for the creation of a wide range of organic compounds. Its unique structure enables chemists to modify and functionalize it in various ways, leading to the formation of new molecules with potential applications in various industries.
Used in the Development of New Chemical Processes:
3-Pyrrolidinemethanol, 1-[(1R)-1-phenylethyl]-, (3R)is utilized in the research and development of innovative chemical processes. Its unique properties and reactivity make it a valuable tool for exploring new reaction pathways and mechanisms, ultimately contributing to the advancement of chemical science and technology.

Upstream product

• 78397-15-6 {[(1R)-1-phenylethyl]amino}acetic acid 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 97-65-4 2-methylenesuccinic acid 
• 99735-45-2 methyl (3R)-1-<(R)-1-phenylethyl>-5-oxo-3-pyrrolidinecarboxylate 
• 617-52-7 Dimethyl itakonate 
• 915302-94-2 (3RS)-1-<(R)-1-phenylethyl>-5-oxo-3-pyrrolidinecarboxylic acid 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Downstream Products

• 138108-72-2 tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate 
• 1210935-33-3 (R)-1-methyl-3-hydroxymethylpyrrolidine 
• 882868-71-5 Benzyl-(S)-1-pyrrolidin-3-ylmethyl-amine 
• 177947-78-3 Benzyl-methyl-(R)-1-pyrrolidin-3-ylmethyl-amine 
• 177948-06-0 (3S)-N-(tert-butyloxycarbonyl)-3-<<(R)-α-(hydroxymethyl)benzyl>aminomethyl>pyrrolidine 

Relevant academic research and scientific papers

Preparation method of chiral 3-substituted pyrrolidine derivative

The invention provides a preparation method of a chiral 3-substituted pyrrolidine derivative. The preparation method comprises an intermediate preparation step, a diastereomer mixture preparation step, a chiral separation step and a chiral 3-substituted pyrrolidine derivative synthesis step. According to the invention, through catalytic asymmetric kinetic resolution, a mixture of two diastereoisomers is efficiently converted into a diastereoisomer with a certain single configuration, chiral separation is realized, a key intermediate is obtained with high yield, and a series of chiral 3-substituted pyrrolidine derivatives are synthesized. The whole reaction route is mild in reaction condition, simple and convenient to operate, high in resolution efficiency, high in atom economy, low in costand suitable for industrial scale production.

4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: Design, synthesis and structure-activity relationships

Single enantiomer [(aryloxy)(pyridinyl)methyl]piperidine and pyrrolidine derivatives 5-9 are inhibitors of monoamine reuptake. Structure-activity relationships established that monoamine reuptake inhibition are functions of amine, pyridine isomer, aryloxy ring substitution and stereochemistry. Consequently, selective NRIs, selective SRIs, dual SNRIs and triple SNDRIs were all identified. Dual SNRIs 5l-a and 9c were evaluated in additional pharmacology and pharmacokinetic studies as representative examples from this series.

GABA Agonists and Uptake Inhibitors. Synthesis, Absolute Stereochemistry, and Enantioselectivity of (R)-(-)- and (S)-(+)-Homo-β-proline

The cyclic analogue of 4-aminobutyric acid (GABA), 3-pyrrolidineacetic acid (homo-β-proline), is a potent agonist at GABAA receptors, it interacts effectively with GABA-uptake mechanisms, and it is a moderately potent inhibitor of GABAB/s