99735-47-4

Basic information

• Product Name: 3-Pyrrolidinemethanol, 1-[(1R)-1-phenylethyl]-, (3R)-
• Synonyms: ((R)-1-((R)-1-phenylethyl)pyrrolidin-3-yl)methanol;(R)-1-[(R)-1-Phenylethyl]-3-pyrrolidineMethanol;(3R)-1-[(1R)-1-Phenylethyl]-3-pyrrolidinemethanol
• CAS NO: 99735-47-4
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.29606
• Mol File: 99735-47-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 88℃
• Boiling Point: 281.1±15.0 °C(Predicted)
• Appearance: /
• Density: 1.058±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.93±0.10(Predicted)
• CAS DataBase Reference: 3-Pyrrolidinemethanol, 1-[(1R)-1-phenylethyl]-, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyrrolidinemethanol, 1-[(1R)-1-phenylethyl]-, (3R)-(99735-47-4)
• EPA Substance Registry System: 3-Pyrrolidinemethanol, 1-[(1R)-1-phenylethyl]-, (3R)-(99735-47-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 99735-47-4(Hazardous Substances Data)

Usage

General Description

3-Pyrrolidinemethanol, 1-[(1R)-1-phenylethyl]-, (3R)- is a chemical compound with a molecular formula of C14H21NO. It is a chiral compound with a three-dimensional structure and is often used in organic synthesis as an intermediate. This chemical is commonly utilized in the production of pharmaceuticals, such as antihistamines and certain types of analgesics. Additionally, it can be used in the synthesis of other organic compounds, as well as in the development of new chemical processes. Due to its versatile nature and potential applications, 3-Pyrrolidinemethanol, 1-[(1R)-1-phenylethyl]-, (3R)- is a valuable compound in the field of organic chemistry.

Upstream product

• 78397-15-6 {[(1R)-1-phenylethyl]amino}acetic acid 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 97-65-4 2-methylenesuccinic acid 
• 617-52-7 Dimethyl itakonate 
• 915302-94-2 (3RS)-1-<(R)-1-phenylethyl>-5-oxo-3-pyrrolidinecarboxylic acid 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 99735-45-2 methyl (3R)-1-<(R)-1-phenylethyl>-5-oxo-3-pyrrolidinecarboxylate 

Downstream Products

• 99735-49-6 Ethyl-[(S)-1-((R)-1-phenyl-ethyl)-pyrrolidin-3-ylmethyl]-amine 
• 138108-72-2 tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate 
• 1210935-33-3 (R)-1-methyl-3-hydroxymethylpyrrolidine 
• 192214-05-4 benzyl (R)-3-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 1436862-03-1 trans-3-[N'-(6-benzyloxy-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carbonyl)-hydrazinocarbonyl]-(R)-pyrrolidin-1-carboxylic acid tert-butyl ester 
• 441717-40-4 (R)-methyl-1-tert-butoxycarbonyl-pyrrolidine-3-carboxylate 
• 1217655-90-7 (R)-methyl-1-benzyloxycarbonyl-pyrrolidine-3-carboxylate 
• 192214-06-5 (R)-1-((benzyloxy)-carbonyl)pyrrolidine-3-carboxylic acid 
• 882868-71-5 Benzyl-(S)-1-pyrrolidin-3-ylmethyl-amine 
• 177947-78-3 Benzyl-methyl-(R)-1-pyrrolidin-3-ylmethyl-amine 

Relevant articles and documents

Preparation method of chiral 3-substituted pyrrolidine derivative

The invention provides a preparation method of a chiral 3-substituted pyrrolidine derivative. The preparation method comprises an intermediate preparation step, a diastereomer mixture preparation step, a chiral separation step and a chiral 3-substituted pyrrolidine derivative synthesis step. According to the invention, through catalytic asymmetric kinetic resolution, a mixture of two diastereoisomers is efficiently converted into a diastereoisomer with a certain single configuration, chiral separation is realized, a key intermediate is obtained with high yield, and a series of chiral 3-substituted pyrrolidine derivatives are synthesized. The whole reaction route is mild in reaction condition, simple and convenient to operate, high in resolution efficiency, high in atom economy, low in costand suitable for industrial scale production.

GABA Agonists and Uptake Inhibitors. Synthesis, Absolute Stereochemistry, and Enantioselectivity of (R)-(-)- and (S)-(+)-Homo-β-proline

The cyclic analogue of 4-aminobutyric acid (GABA), 3-pyrrolidineacetic acid (homo-β-proline), is a potent agonist at GABAA receptors, it interacts effectively with GABA-uptake mechanisms, and it is a moderately potent inhibitor of GABAB/s