C₁₂H₁₄N₂O₃

Base Information

• Chemical Name: C₁₂H₁₄N₂O₃
• CAS No.: 1414689-37-4
• Molecular Formula: C₁₂H₁₄N₂O₃
• Molecular Weight: 234.255
• Mol file: 1414689-37-4.mol

Synonyms:C₁₂H₁₄N₂O₃

Chemical Property of C₁₂H₁₄N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₄N₂O₃

There total 3 articles about C₁₂H₁₄N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

phosgene (75-44-5) + C11H16N2O2*C2HF3O2 (1414689-21-6) → C12H14N2O3 (1414689-37-4)

Guidance literature:

C₁₁H₁₆N₂O₂*C₂HF₃O₂; With sodium hydrogencarbonate; In dichloromethane; for 0.00833333h;

phosgene; In dichloromethane; toluene; for 0.333333h;

DOI:10.1016/j.tetlet.2012.09.025

Reference yield:

N-methyl-O-benzylhydroxylamine (22513-22-0) → C12H14N2O3 (1414689-37-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: dichloromethane / 20 °C

3.1: sodium hydrogencarbonate / dichloromethane / 0.01 h

3.2: 0.33 h

With sodium hydrogencarbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2012.09.025

Reference yield:

benzyl 3-(t-butoxycarbonylamino)propanohydroxamate (136413-17-7) → C12H14N2O3 (1414689-37-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 40 °C

2.1: dichloromethane / 20 °C

3.1: sodium hydrogencarbonate / dichloromethane / 0.01 h

3.2: 0.33 h

With sodium hydrogencarbonate; potassium carbonate; In dichloromethane; acetonitrile;

DOI:10.1016/j.tetlet.2012.09.025

upstream raw materials:

phosgene

C₁₁H₁₆N₂O₂*C₂HF₃O₂

benzyl 3-(t-butoxycarbonylamino)propanohydroxamate

N-methyl-O-benzylhydroxylamine

Downstream raw materials:

C₂₀H₃₃N₃O₃

C₄₂H₅₇N₇O₁₂

C₄₂H₆₀N₁₀O₉