1-O-(tert-butyldimethylsilyl)-3-[2-(N-Boc-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropan-1-ol

Base Information

Chemical Name:1-O-(tert-butyldimethylsilyl)-3-[2-(N-Boc-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropan-1-ol
CAS No.:380306-30-9
Molecular Formula:C₂₉H₅₁NO₅Si
Molecular Weight:521.813
Hs Code.:

Synonyms:1-O-(tert-butyldimethylsilyl)-3-[2-(N-Boc-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropan-1-ol

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Chemical Property of 1-O-(tert-butyldimethylsilyl)-3-[2-(N-Boc-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropan-1-ol

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Technology Process of 1-O-(tert-butyldimethylsilyl)-3-[2-(N-Boc-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropan-1-ol

There total 1 articles about 1-O-(tert-butyldimethylsilyl)-3-[2-(N-Boc-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 13734-41-3
t-Boc-L-valine

: 134098-64-9
2‐{3‐[(O‐tert‐butyldimethylsilyl)hydroxy]‐1,1‐dimethylpropyl}‐3,5‐dimethylphenol

: 380306-30-9
1-O-(tert-butyldimethylsilyl)-3-[2-(N-Boc-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropan-1-ol

Guidance literature:: t-Boc-L-valine; 2‐{3‐[(O‐tert‐butyldimethylsilyl)hydroxy]‐1,1‐dimethylpropyl}‐3,5‐dimethylphenol; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

With hydrogenchloride; In dichloromethane; water;

Reference yield:

: 380306-30-9
1-O-(tert-butyldimethylsilyl)-3-[2-(N-Boc-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropan-1-ol

: 1034191-61-1
2-tert-butoxycarbonylamino-3-methyl-butyric acid 2-(3-hydroxy-1,1-dimethyl-propyl)-3,5-dimethyl-phenyl ester

Guidance literature:: With acetic acid; In tetrahydrofuran; water; at 20 ℃; for 1h;
DOI:10.1002/1521-4184(200106)334:6<209::AID-ARDP209>3.0.CO;2-Y

Reference yield:

: 380306-30-9
1-O-(tert-butyldimethylsilyl)-3-[2-(N-Boc-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropan-1-ol

: 380306-41-2
3-[2-(N-Boc-L-valyloxy)-4,6-dimethylphenyl]-3,3-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: glac. HOAc / tetrahydrofuran; H₂O / 1 h / 20 °C

2: pyridinium chlorochromate / CH₂Cl₂

3: 204 mg / NaH₂PO₄; NaClO₂ / H₂O; acetonitrile / 0 - 20 °C

With sodium chlorite; sodium dihydrogenphosphate; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1002/1521-4184(200106)334:6<209::AID-ARDP209>3.0.CO;2-Y