(R)-benzyl 2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (R)-benzyl 2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)pyrrolidine-1-carboxylate
• CAS No.: 1140496-45-2
• Molecular Formula: C₂₀H₂₀ClN₅O₂
• Molecular Weight: 397.864
• Mol file: 1140496-45-2.mol

Synonyms:(R)-benzyl 2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)pyrrolidine-1-carboxylate

Chemical Property of (R)-benzyl 2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (R)-benzyl 2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)pyrrolidine-1-carboxylate

There total 2 articles about (R)-benzyl 2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-2-(1H-tetrazol-5-yl)-pyrrolidine-1-carboxylic acid benzyl ester (839711-73-8) + 4-chlorobenzyl bromide (622-95-7) → (R)-benzyl 2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)pyrrolidine-1-carboxylate (1140496-45-2) + C20H20ClN5O2 (1140496-46-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

4-chlorobenzyl bromide (622-95-7) + (+)-(R)-2-cyano-pyrrolidine-1-carboxylic acid benzyl ester (620601-77-6) → (R)-benzyl 2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)pyrrolidine-1-carboxylate (1140496-45-2) + C20H20ClN5O2 (1140496-46-3)

Guidance literature:

(+)-(R)-2-cyano-pyrrolidine-1-carboxylic acid benzyl ester; With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 90 ℃; for 16h;

4-chlorobenzyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2010.07.082

Reference yield: 31.0%

(R)-benzyl 2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)pyrrolidine-1-carboxylate (1140496-45-2) → (R)-1-(4-chlorobenzyl)-5-(pyrrolidin-2-yl)-1H-tetrazole (1140496-49-6) + (R)-1-(4-chlorobenzyl)-5-(pyrrolidin-2-yl)-1H-tetrazole hydrochloride (1140496-50-9)

Guidance literature:

(R)-benzyl 2-(1-(4-chlorobenzyl)-1H-tetrazol-5-yl)pyrrolidine-1-carboxylate; With trimethylsilyl iodide; In acetonitrile; at 20 ℃; for 0.5h;

With hydrogenchloride; water;

With sodium hydroxide; In water; at 0 ℃; pH=10 - 12;

upstream raw materials:

(2R)-2-(1H-tetrazol-5-yl)-pyrrolidine-1-carboxylic acid benzyl ester

4-chlorobenzyl bromide

(+)-(R)-2-cyano-pyrrolidine-1-carboxylic acid benzyl ester

Downstream raw materials:

(R)-1-(4-chlorobenzyl)-5-(pyrrolidin-2-yl)-1H-tetrazole

(R)-1-(4-chlorobenzyl)-5-(pyrrolidin-2-yl)-1H-tetrazole hydrochloride