(r)-1-Cbz-2-cyanopyrrolidine

Base Information

Chemical Name:(r)-1-Cbz-2-cyanopyrrolidine
CAS No.:620601-77-6
Molecular Formula:C13H14N2O2
Molecular Weight:230.266
Hs Code.:2933990090
European Community (EC) Number:674-832-3
DSSTox Substance ID:DTXSID40466186
Nikkaji Number:J1.783.505J
Wikidata:Q72516123
Mol file:620601-77-6.mol

Synonyms:620601-77-6;(r)-1-cbz-2-cyanopyrrolidine;(R)-1-CBZ-2-CYANO-PYRROLIDINE;benzyl (2R)-2-cyanopyrrolidine-1-carboxylate;(r)-benzyl 2-cyanopyrrolidine-1-carboxylate;MFCD06796619;(r)-1-n-cbz-2-cyano-pyrrolidine;SCHEMBL1437419;DTXSID40466186;AUVGQGIWVNDVSL-GFCCVEGCSA-N;AKOS015836813;AS-38676;A8583;Benzyl (R)-2-cyanopyrrolidine-1-carboxylate;CS-0146417;Q-102180;(r)-2-cyano-pyrrolidine-1-carboxylic acid benzyl ester

Suppliers and Price of (r)-1-Cbz-2-cyanopyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-1-Cbz-2-cyanopyrrolidine
100mg
$ 60.00

TRC
(R)-1-Cbz-2-cyanopyrrolidine
50mg
$ 45.00

Crysdot
(R)-1-Cbz-2-Cyanopyrrolidine 97%
5g
$ 353.00

Chemenu
(R)-1-Cbz-2-cyano-pyrrolidine 95+%
5g
$ 330.00

American Custom Chemicals Corporation
(R)-2-CYANO-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER 95.00%
1G
$ 300.30

American Custom Chemicals Corporation
(R)-2-CYANO-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER 95.00%
5G
$ 1091.48

Alichem
(R)-1-Cbz-2-Cyanopyrrolidine
10g
$ 615.30

AK Scientific
(R)-1-Cbz-2-Cyanopyrrolidine
1g
$ 250.00

Activate Scientific
(R)-1-Cbz-2-Cyanopyrrolidine 95+% ee
5 g
$ 697.00

Activate Scientific
(R)-1-Cbz-2-Cyanopyrrolidine 95+% ee
1 g
$ 229.00

Total 38 raw suppliers

Chemical Property of (r)-1-Cbz-2-cyanopyrrolidine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.573
Boiling Point:403.618 °C at 760 mmHg
PKA:-5.02±0.40(Predicted)
Flash Point:197.902 °C
PSA：53.33000
Density:1.208 g/cm³
LogP:2.24908
Storage Temp.:2-8°C
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:230.105527694
Heavy Atom Count:17
Complexity:315

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-Cbz-2-cyanopyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(N(C1)C(=O)OCC2=CC=CC=C2)C#N
Isomeric SMILES:C1C[C@@H](N(C1)C(=O)OCC2=CC=CC=C2)C#N

Technology Process of (r)-1-Cbz-2-cyanopyrrolidine

There total 2 articles about (r)-1-Cbz-2-cyanopyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 62937-47-7,58274-22-9
(2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid benzyl ester

: 620601-77-6
(+)-(R)-2-cyano-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With pyridine; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 72h;
DOI:10.1039/b414742a

Reference yield:

: 6404-31-5
Z-D-proline

: 620601-77-6
(+)-(R)-2-cyano-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxybenzotriazole; EDCI / tetrahydrofuran / 0.5 h / 20 °C

1.2: 68 percent / aq. NH₃ / tetrahydrofuran / 24 h / 20 °C

2.1: 64 percent / p-TsCl; pyridine / CH₂Cl₂ / 72 h / 20 °C

With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; p-toluenesulfonyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b414742a