2-chloro-6-morpholinobenzonitrile

Base Information

• Chemical Name: 2-chloro-6-morpholinobenzonitrile
• CAS No.: 20925-56-8
• Molecular Formula: C₁₁H₁₁ClN₂O
• Molecular Weight: 222.674
• Mol file: 20925-56-8.mol

Synonyms:2-chloro-6-morpholinobenzonitrile

Chemical Property of 2-chloro-6-morpholinobenzonitrile

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-6-morpholinobenzonitrile

There total 3 articles about 2-chloro-6-morpholinobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-(benzoyloxy)morpholine (5765-65-1) + zinc(II) cyanide (557-21-1) + 2-iodochlorobenzene (615-41-8) → 2-chloro-6-morpholinobenzonitrile (20925-56-8)

Guidance literature:

With norbornene; palladium diacetate; caesium carbonate; triphenylphosphine; In toluene; at 120 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02249

Reference yield: 63.0%

4-(benzoyloxy)morpholine (5765-65-1) + potassiumhexacyanoferrate(II) trihydrate + 2-iodochlorobenzene (615-41-8) → 2-chloro-6-morpholinobenzonitrile (20925-56-8)

Guidance literature:

With norborn-2-ene; palladium diacetate; caesium carbonate; triphenylphosphine; In toluene; at 100 ℃; for 14.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02113

Reference yield:

morpholine (110-91-8,99108-56-2) + 2,6-dichloro-benzonitrile (1194-65-6) → 2-chloro-6-morpholinobenzonitrile (20925-56-8)

Guidance literature:

upstream raw materials:

morpholine

2,6-dichloro-benzonitrile

4-(benzoyloxy)morpholine

zinc(II) cyanide