3-(4-aminophenoxy)-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-methylpropanamine

Base Information

Chemical Name:3-(4-aminophenoxy)-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-methylpropanamine
CAS No.:143665-62-7
Molecular Formula:C₂₀H₂₈N₂O₃
Molecular Weight:344.454
Hs Code.:

Synonyms:3-(4-aminophenoxy)-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-methylpropanamine

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Chemical Property of 3-(4-aminophenoxy)-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-methylpropanamine

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Technology Process of 3-(4-aminophenoxy)-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-methylpropanamine

There total 7 articles about 3-(4-aminophenoxy)-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-methylpropanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 143665-61-6
N-<2-(3,4-dimethoxyphenyl)ethyl>-N-methyl-3-(4-nitrophenoxy)propanamine

: 143665-62-7
3-(4-aminophenoxy)-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-methylpropanamine

Guidance literature:: With tin(ll) chloride; In ethanol; for 2h; Heating;
DOI:10.1016/S0968-0896(98)00166-7

Reference yield:

: 3490-06-0
N-methylhomoveratrylamine

: 143665-62-7
3-(4-aminophenoxy)-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-methylpropanamine

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / potassium fluoride on Celite / acetonitrile / 20 h / 85 °C

2: 76 percent / NaH / dimethylsulfoxide / 1 h / Ambient temperature

3: 77 percent / SnCl₂-2H₂O / ethanol / 2 h / Heating

With potassium fluoride on Celite; sodium hydride; tin(ll) chloride; In ethanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0968-0896(98)00166-7

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 143665-62-7
3-(4-aminophenoxy)-N-<2-(3,4-dimethoxyphenyl)ethyl>-N-methylpropanamine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) K₂CO₃ / 1.) DMF, RT, 1 h, 2.) DMF, overnight

2: 0.5 h / 140 °C

3: H₂ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00013a017