(2R,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-N-[(4-methoxyphenyl)methyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-amine

Base Information

Chemical Name:(2R,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-N-[(4-methoxyphenyl)methyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-amine
CAS No.:1619983-11-7
Molecular Formula:C₃₁H₄₃NO₄
Molecular Weight:493.687
Hs Code.:

Synonyms:(2R,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-N-[(4-methoxyphenyl)methyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-amine

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Chemical Property of (2R,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-N-[(4-methoxyphenyl)methyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-amine

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Technology Process of (2R,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-N-[(4-methoxyphenyl)methyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-amine

There total 6 articles about (2R,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-N-[(4-methoxyphenyl)methyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1619983-10-6
(3R,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-one

: 2393-23-9
4-methoxy-benzylamine

: 1619983-11-7
(2R,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-N-[(4-methoxyphenyl)methyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-amine

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 22.5h; Inert atmosphere;

Reference yield:

: (1S,2R,4aS,8aS)-1-[(3,5-dimethoxyphenyl)(hydroxy)methyl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

: 1619983-11-7
(2R,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-N-[(4-methoxyphenyl)methyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C

2.1: tin(IV) chloride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere

3.2: 1.33 h / 0 - 65 °C

4.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C

5.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 22.5 h / 20 °C / Inert atmosphere

With borane-THF; tin(IV) chloride; sodium tris(acetoxy)borohydride; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1619983-08-2
[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](3,5-dimethoxyphenyl)methanone

: 1619983-11-7
(2R,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-N-[(4-methoxyphenyl)methyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere

1.2: 1.33 h / 0 - 65 °C

2.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 22.5 h / 20 °C / Inert atmosphere

With borane-THF; sodium tris(acetoxy)borohydride; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;