(1aR,12bS)-8-cyclohexyl-N-(N,N-dimethylsulfamoyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(9-methyl-3,9-diazabicyclo[4.2.1]nonane-3-carbonyl)cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide trifluoroacetate

Base Information

Chemical Name:(1aR,12bS)-8-cyclohexyl-N-(N,N-dimethylsulfamoyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(9-methyl-3,9-diazabicyclo[4.2.1]nonane-3-carbonyl)cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide trifluoroacetate
CAS No.:1059700-87-6
Molecular Formula:C₂HF₃O₂*C₃₇H₄₇N₅O₅S
Molecular Weight:787.901
Hs Code.:

(1aR,12bS)-8-cyclohexyl-N-(N,N-dimethylsulfamoyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(9-methyl-3,9-diazabicyclo[4.2.1]nonane-3-carbonyl)cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide trifluoroacetate

Synonyms:(1aR,12bS)-8-cyclohexyl-N-(N,N-dimethylsulfamoyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(9-methyl-3,9-diazabicyclo[4.2.1]nonane-3-carbonyl)cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide trifluoroacetate

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Chemical Property of (1aR,12bS)-8-cyclohexyl-N-(N,N-dimethylsulfamoyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(9-methyl-3,9-diazabicyclo[4.2.1]nonane-3-carbonyl)cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide trifluoroacetate

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Technology Process of (1aR,12bS)-8-cyclohexyl-N-(N,N-dimethylsulfamoyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(9-methyl-3,9-diazabicyclo[4.2.1]nonane-3-carbonyl)cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide trifluoroacetate

There total 3 articles about (1aR,12bS)-8-cyclohexyl-N-(N,N-dimethylsulfamoyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(9-methyl-3,9-diazabicyclo[4.2.1]nonane-3-carbonyl)cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 928843-71-4
(1aR,12bS)-8-cyclohexyl-5-[[[(dimethylamino)sulfonyl]amino]carbonyl]-1,12b-dihydro-11-methoxycycloprop[d]indolo[2,1-a][2]benzazepine-1a(2H)-carboxylic acid

: 102547-84-2
9-methyl-3,9-diazabicyclo[4.2.1]nonane

: 1059700-87-6
(1aR,12bS)-8-cyclohexyl-N-(N,N-dimethylsulfamoyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(9-methyl-3,9-diazabicyclo[4.2.1]nonane-3-carbonyl)cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide trifluoroacetate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; at 20 ℃; for 0.5 - 0.75h;

Reference yield:

: 532-24-1
tropinone

: 1059700-87-6
(1aR,12bS)-8-cyclohexyl-N-(N,N-dimethylsulfamoyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(9-methyl-3,9-diazabicyclo[4.2.1]nonane-3-carbonyl)cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide; sulfuric acid / chloroform / 4 h / -5 - 50 °C

1.2: 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 - 4 h / Heating / reflux

2.2: 0.5 h / 0 °C

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.5 - 0.75 h / 20 °C

With lithium aluminium tetrahydride; sodium azide; sulfuric acid; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; dichloromethane; chloroform;

Reference yield:

: 7309-42-4
(+/-)-9-methyl-3,9-diazabicyclo[4.2.1]nonan-4-one

: 1059700-87-6
(1aR,12bS)-8-cyclohexyl-N-(N,N-dimethylsulfamoyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(9-methyl-3,9-diazabicyclo[4.2.1]nonane-3-carbonyl)cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 - 4 h / Heating / reflux

1.2: 0.5 h / 0 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.5 - 0.75 h / 20 °C

With lithium aluminium tetrahydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; dichloromethane;