trans-methanesulfonic acid 4-{2-[methyl-(4-trifluoromethylphenoxycarbonyl)amino]ethyl}cyclohexylmethyl ester

Base Information

Chemical Name:trans-methanesulfonic acid 4-{2-[methyl-(4-trifluoromethylphenoxycarbonyl)amino]ethyl}cyclohexylmethyl ester
CAS No.:554455-02-6
Molecular Formula:C₁₉H₂₆F₃NO₅S
Molecular Weight:437.48
Hs Code.:

Synonyms:trans-methanesulfonic acid 4-{2-[methyl-(4-trifluoromethylphenoxycarbonyl)amino]ethyl}cyclohexylmethyl ester

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Chemical Property of trans-methanesulfonic acid 4-{2-[methyl-(4-trifluoromethylphenoxycarbonyl)amino]ethyl}cyclohexylmethyl ester

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Technology Process of trans-methanesulfonic acid 4-{2-[methyl-(4-trifluoromethylphenoxycarbonyl)amino]ethyl}cyclohexylmethyl ester

There total 7 articles about trans-methanesulfonic acid 4-{2-[methyl-(4-trifluoromethylphenoxycarbonyl)amino]ethyl}cyclohexylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 554455-00-4
trans-methanesulfonic acid 4-(2-methylaminoethyl)cyclohexylmethyl ester hydrochloride

: 1379455-59-0
imidazole-1-carboxylic acid 4-(trifluoromethyl)phenyl ester

: 554455-02-6
trans-methanesulfonic acid 4-{2-[methyl-(4-trifluoromethylphenoxycarbonyl)amino]ethyl}cyclohexylmethyl ester

Guidance literature:: imidazole-1-carboxylic acid 4-(trifluoromethyl)phenyl ester; With dimethyl sulfate; In acetonitrile; at 20 - 80 ℃; for 2h;

trans-methanesulfonic acid 4-(2-methylaminoethyl)cyclohexylmethyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm300256z

Reference yield:

: 180046-64-4
C₁₅H₂₉NOSi

: 554455-02-6
trans-methanesulfonic acid 4-{2-[methyl-(4-trifluoromethylphenoxycarbonyl)amino]ethyl}cyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: platinum(IV) oxide; hydrogen / ethanol / 20 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 3.17 h / 20 °C

3.1: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5.1: potassium carbonate / methanol / 2 h / 20 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

8.1: dimethyl sulfate / acetonitrile / 2 h / 20 - 80 °C

8.2: 1 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; platinum(IV) oxide; hydrogen; sodium hydride; potassium carbonate; triethylamine; dimethyl sulfate; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm300256z

Reference yield:

: 553676-91-8
trans-[4-(2-aminoethyl)cyclohexyl]methanol hydrochloride

: 554455-02-6
trans-methanesulfonic acid 4-{2-[methyl-(4-trifluoromethylphenoxycarbonyl)amino]ethyl}cyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 3.17 h / 20 °C

2.1: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: potassium carbonate / methanol / 2 h / 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

6.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

7.1: dimethyl sulfate / acetonitrile / 2 h / 20 - 80 °C

7.2: 1 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; sodium hydride; potassium carbonate; triethylamine; dimethyl sulfate; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm300256z