trans-methanesulfonic acid 4-(2-methylaminoethyl)cyclohexylmethyl ester hydrochloride

Base Information

Chemical Name:trans-methanesulfonic acid 4-(2-methylaminoethyl)cyclohexylmethyl ester hydrochloride
CAS No.:554455-00-4
Molecular Formula:C₁₁H₂₃NO₃S*ClH
Molecular Weight:285.835
Hs Code.:

Synonyms:trans-methanesulfonic acid 4-(2-methylaminoethyl)cyclohexylmethyl ester hydrochloride

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Chemical Property of trans-methanesulfonic acid 4-(2-methylaminoethyl)cyclohexylmethyl ester hydrochloride

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Technology Process of trans-methanesulfonic acid 4-(2-methylaminoethyl)cyclohexylmethyl ester hydrochloride

There total 6 articles about trans-methanesulfonic acid 4-(2-methylaminoethyl)cyclohexylmethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 554454-99-8
trans-methanesulfonic acid 4-[2-(tert-butoxycarbonyl-methyl-amino)ethyl]cyclohexylmethyl ester

: 554455-00-4
trans-methanesulfonic acid 4-(2-methylaminoethyl)cyclohexylmethyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1021/jm300256z

Reference yield:

: trans-[2-(4-hydroxymethyl-cyclohexyl)-ethyl]-methyl-carbamic acid tert-butyl ester

: 124-63-0
methanesulfonyl chloride

: trans-methanesulfonic acid 4-[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-cyclohexylmethyl ester

: 554455-00-4
trans-methanesulfonic acid 4-(2-methylaminoethyl)cyclohexylmethyl ester hydrochloride

Guidance literature:

Reference yield:

: 180046-64-4
C₁₅H₂₉NOSi

: 554455-00-4
trans-methanesulfonic acid 4-(2-methylaminoethyl)cyclohexylmethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: platinum(IV) oxide; hydrogen / ethanol / 20 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 3.17 h / 20 °C

3: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

4: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: potassium carbonate / methanol / 2 h / 20 °C / Inert atmosphere

6: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

7: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With pyridine; hydrogenchloride; platinum(IV) oxide; hydrogen; sodium hydride; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm300256z