methyl 5-(2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)-6-nitrobenzofuran-5-yl)-2-methoxybenzoate

Base Information

Chemical Name:methyl 5-(2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)-6-nitrobenzofuran-5-yl)-2-methoxybenzoate
CAS No.:1449332-95-9
Molecular Formula:C₂₆H₁₈FN₃O₆
Molecular Weight:487.444
Hs Code.:

Synonyms:methyl 5-(2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)-6-nitrobenzofuran-5-yl)-2-methoxybenzoate

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Chemical Property of methyl 5-(2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)-6-nitrobenzofuran-5-yl)-2-methoxybenzoate

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Technology Process of methyl 5-(2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)-6-nitrobenzofuran-5-yl)-2-methoxybenzoate

There total 8 articles about methyl 5-(2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)-6-nitrobenzofuran-5-yl)-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 478375-37-0
methyl 2-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoate

: 2-(4-fluorophenyl)-6-nitro-3-(1-((trifluoromethyl)sulfonyl)-1H-imidazol-2-yl)benzofuran-5-yl trifluoromethanesulfonate

: 1449332-95-9
methyl 5-(2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)-6-nitrobenzofuran-5-yl)-2-methoxybenzoate

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 20 - 100 ℃;

Reference yield:

: 691857-03-1
2-(4-fluorophenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylic acid

: 1449332-95-9
methyl 5-(2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)-6-nitrobenzofuran-5-yl)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 7 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

3: trichlorophosphate / toluene / 20 - 100 °C / Inert atmosphere

4: Dess-Martin periodane / dimethyl sulfoxide / 20 °C

5: boron trichloride / dichloromethane / -78 - 20 °C

6: pyridine; dmap / 24 h / 0 - 20 °C

7: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 20 - 100 °C

With pyridine; hydrogenchloride; dmap; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; boron trichloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 691857-07-5
ethyl 2-(4-fluorophenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

: 1449332-95-9
methyl 5-(2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)-6-nitrobenzofuran-5-yl)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 8 steps

1: water; sodium hydroxide / tetrahydrofuran; water / 20 - 50 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane / 20 °C

4: trichlorophosphate / toluene / 20 - 100 °C / Inert atmosphere

5: Dess-Martin periodane / dimethyl sulfoxide / 20 °C

6: boron trichloride / dichloromethane / -78 - 20 °C

7: pyridine; dmap / 24 h / 0 - 20 °C

8: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 20 - 100 °C

With pyridine; hydrogenchloride; dmap; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; boron trichloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;