tert-butyl 2-(2-(4-fluorophenyl)-5-(4-methoxy-3-((1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl)-6-nitrobenzofuran-3-yl)-1H-imidazole-1-carboxylate

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Chemical Name:tert-butyl 2-(2-(4-fluorophenyl)-5-(4-methoxy-3-((1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl)-6-nitrobenzofuran-3-yl)-1H-imidazole-1-carboxylate
CAS No.:1449332-98-2
Molecular Formula:C₃₇H₃₁FN₆O₇
Molecular Weight:690.688
Hs Code.:

tert-butyl 2-(2-(4-fluorophenyl)-5-(4-methoxy-3-((1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl)-6-nitrobenzofuran-3-yl)-1H-imidazole-1-carboxylate

Synonyms:tert-butyl 2-(2-(4-fluorophenyl)-5-(4-methoxy-3-((1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl)-6-nitrobenzofuran-3-yl)-1H-imidazole-1-carboxylate

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Chemical Property of tert-butyl 2-(2-(4-fluorophenyl)-5-(4-methoxy-3-((1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl)-6-nitrobenzofuran-3-yl)-1H-imidazole-1-carboxylate

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Technology Process of tert-butyl 2-(2-(4-fluorophenyl)-5-(4-methoxy-3-((1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl)-6-nitrobenzofuran-3-yl)-1H-imidazole-1-carboxylate

There total 11 articles about tert-butyl 2-(2-(4-fluorophenyl)-5-(4-methoxy-3-((1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl)-6-nitrobenzofuran-3-yl)-1H-imidazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1449332-97-1
5-(2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)-6-nitrobenzofuran-5-yl)-2-methoxy-N-(1-(pyrimidin-2-yl)cyclopropyl)benzamide

: 1449332-98-2
tert-butyl 2-(2-(4-fluorophenyl)-5-(4-methoxy-3-((1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl)-6-nitrobenzofuran-3-yl)-1H-imidazole-1-carboxylate

Guidance literature:: With dmap; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1449332-95-9
methyl 5-(2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)-6-nitrobenzofuran-5-yl)-2-methoxybenzoate

: 1449332-98-2
tert-butyl 2-(2-(4-fluorophenyl)-5-(4-methoxy-3-((1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl)-6-nitrobenzofuran-3-yl)-1H-imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / tetrahydrofuran / 20 - 50 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3: dmap / tetrahydrofuran / 20 °C

With dmap; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1449332-96-0
5-(2-(4-fluorophenyl)-3-(1H-imidazol-2-yl)-6-nitrobenzofuran-5-yl)-2-methoxybenzoic acid

: 1449332-98-2
tert-butyl 2-(2-(4-fluorophenyl)-5-(4-methoxy-3-((1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl)-6-nitrobenzofuran-3-yl)-1H-imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: dmap / tetrahydrofuran / 20 °C

With dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;