2-Chloro-6-hydroxynicotinic acid

Base Information

• Chemical Name: 2-Chloro-6-hydroxynicotinic acid
• CAS No.: 38025-90-0
• Molecular Formula: C₆H₄ClNO₃
• Molecular Weight: 173.556
• Hs Code.: 2933399090
• Mol file: 38025-90-0.mol

Synonyms:2-Chloro-6-oxo-1,6-dihydropyridine-3-carboxylic acid;

Chemical Property of 2-Chloro-6-hydroxynicotinic acid

Chemical Property:

• Vapor Pressure: 2.77E-10mmHg at 25°C
• Melting Point: 302°C(lit.)
• Refractive Index: 1.64
• Boiling Point: 486.65 °C at 760 mmHg
• Flash Point: 248.117 °C
• PSA: 70.42000
• Density: 1.644 g/cm³
• LogP: 1.13880
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-6-hydroxynicotinic Acid 95-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-6-hydroxynicotinic acid

There total 4 articles about 2-Chloro-6-hydroxynicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,6-dichloropyridine-3-carboxylic acid (38496-18-3) → 2-chloro-6-oxo-1,6-dihydropyridine-3-carboxylic acid (38025-90-0)

Guidance literature:

With water; sodium hydroxide; at 129 ℃; for 4h;

Reference yield: 48.0%

→ 2-chloro-6-oxo-1,6-dihydropyridine-3-carboxylic acid (38025-90-0)

Guidance literature:

Reference yield:

2,4-dichloronicotinic acid (262423-77-8) → 2-chloro-6-oxo-1,6-dihydropyridine-3-carboxylic acid (38025-90-0)

Guidance literature:

upstream raw materials:

2,4-dichloronicotinic acid

2,6-dichloropyridine-3-carboxylic acid

Downstream raw materials:

2-(2-fluoro-4-iodophenylamino)-1,5-dimethyl-6-oxo-N-(2-(vinyloxy)ethoxy)-1,6-dihydropyridine-3-carboxamide

2-[(2-fluoro-4-iodoiodophenyl)amino]-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide

2-(2-fluoro-4-iodo-anilino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid methyl ester

methyl 5-bromo-2-chloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Refernces

• 1、 -. "DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS". Page/Page column 97. . Retrieved 2010/11/03.
• 2、 -. "COMBINATION THERAPY COMPRISING AZD2171 AND AZD6244 OR MEK-INHIBITOR II". Page/Page column 33. . Retrieved 2008/12/08.