2,4-dichloropyridine-3-carboxylic Acid

Base Information

• Chemical Name: 2,4-dichloropyridine-3-carboxylic Acid
• CAS No.: 262423-77-8
• Molecular Formula: C6H3Cl2NO2
• Molecular Weight: 192.001
• Hs Code.: 2933399090
• European Community (EC) Number: 686-983-2
• DSSTox Substance ID: DTXSID40442046
• Nikkaji Number: J1.537.720H
• Wikidata: Q72467985
• Mol file: 262423-77-8.mol

Synonyms:2,4-dichloropyridine-3-carboxylic Acid;262423-77-8;2,4-dichloronicotinic acid;2,4-Dichloronicotinc Acid;2,4-Dichloro-3-pyridinecarboxylic acid;2,4-Dichloronicotinicacid;MFCD06796292;2.4-dichloronicotinic Acid;2,4-DichloronicotincAcid;2,4-Dichloro-nicotinic acid;SCHEMBL392396;DTXSID40442046;ZFGZNVSNOJPGDV-UHFFFAOYSA-N;CS-D1387;BBL104095;STL557910;AKOS005071888;AC-5065;BC-0803;PB21990;2?4-dichloropyridine-3-carboxylic acid;SY005510;3-Pyridinecarboxylic acid, 2,4-dichloro-;A5216;AM20070221;D4901;FT-0650037;EN300-96140;2,4-Dichloropyridine-3-carboxylic acid, 97%;J-507187;Z1741969747

Chemical Property of 2,4-dichloropyridine-3-carboxylic Acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 166-167°C
• Refractive Index: 1.606
• Boiling Point: 325.17 °C at 760 mmHg
• PKA: 0.79±0.25(Predicted)
• Flash Point: 150.458 °C
• PSA: 50.19000
• Density: 1.612 g/cm³
• LogP: 2.08660
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 190.9540837
• Heavy Atom Count: 11
• Complexity: 165

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dichloropyridine-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C(=C1Cl)C(=O)O)Cl
• Uses: 2,4-Dichloropyridine-3-carboxylic Acid is useful for the preparation of prolyl hydroxylase inhibitors or erythropoietin inducing agents.

Technology Process of 2,4-dichloropyridine-3-carboxylic Acid

There total 7 articles about 2,4-dichloropyridine-3-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,4-dichloropyridine (26452-80-2) + carbon dioxide (124-38-9,18923-20-1) → 2,4-dichloronicotinic acid (262423-77-8)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

Reference yield: 82.0%

carbon dioxide (124-38-9,18923-20-1) → 2,4-dichloronicotinic acid (262423-77-8)

Guidance literature:

2,4-dichloropyridine; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

carbon dioxide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.166667h;

With hydrogenchloride; water; pH=4;

Reference yield: 70.0%

2,4-dichloropyridine (26452-80-2) → 2,4-dichloronicotinic acid (262423-77-8)

Guidance literature:

2,4-dichloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; benzene; at -78 ℃; for 2h;

With carbon dioxide; at -78 - 20 ℃;

With hydrogenchloride; potassium hydroxide; water; more than 3 stages;

upstream raw materials:

2,4-dichloropyridine

carbon dioxide

2,4-dichloro-3-iodo-pyridine

2-chloropyridine

Downstream raw materials:

methyl 2,4-dichloronicotinate

C₂₇H₂₅Cl₂N₅O₅

(5-(3-chlorophenyl)-7-hydroxy-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine

tert-butyl (7-(benzyloxy)-[1,2,4]triazolo[4,3-a]pyridine-8-carbonyl)glycinate

Refernces

• 1、 -. "ARYL LACTAM KINASE INHIBITORS". Page/Page column 92. . Retrieved 2015/11/02.
• 2、 Dai, Yujia,Hartandi, Kresna,Soni, Niru B.,Pease, Lori J.,Reuter, David R.,Olson, Amanda M.,Osterling, Donald J.,Doktor, Stella Z.,Albert, Daniel H.,Bouska, Jennifer J.,Glaser, Keith B.,Marcotte, Patrick A.,Stewart, Kent D.,Davidsen, Steven K.,Michaelides, Michael R.. "Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors". . p. 386 - 390. Retrieved 2008/04/03.