4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)-2-hydroxybenzoic acid

Base Information

Chemical Name:4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)-2-hydroxybenzoic acid
CAS No.:1334492-95-3
Molecular Formula:C₂₇H₃₂N₄O₆S
Molecular Weight:540.64
Hs Code.:

Synonyms:4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)-2-hydroxybenzoic acid

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Chemical Property of 4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)-2-hydroxybenzoic acid

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Technology Process of 4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)-2-hydroxybenzoic acid

There total 9 articles about 4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)-2-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1334493-36-5
benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)benzoate

: 1334492-95-3
4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)-2-hydroxybenzoic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.06.056

Reference yield: 98.0%

: 1334492-95-3
4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)-2-hydroxybenzoic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; for 3h;

Reference yield:

: 1241832-99-4
benzyl 4-amino-2-(benzyloxy)benzoate

: 1334492-95-3
4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)-2-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / methanol / 3 h / 45 °C / Inert atmosphere; Molecular sieve

2: sodium cyanoborohydride / methanol / 20 °C / Inert atmosphere

3: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 0.17 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

6: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; dichloromethane; chloroform; water;
DOI:10.1016/j.bmcl.2011.06.056