benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)benzoate

Base Information

Chemical Name:benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)benzoate
CAS No.:1334493-36-5
Molecular Formula:C₄₁H₄₄N₄O₆S
Molecular Weight:720.89
Hs Code.:

Synonyms:benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)benzoate

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Chemical Property of benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)benzoate

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Technology Process of benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)benzoate

There total 9 articles about benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1334493-20-7
benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(methylamino)-acetamido)benzoate

: 137049-00-4
1-methyl-1H-imidazole-4-sulfonyl chloride

: 1334493-36-5
benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.06.056

Reference yield: 95.0%

: 1334493-36-5
benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h; Inert atmosphere;

Reference yield:

: 1241832-99-4
benzyl 4-amino-2-(benzyloxy)benzoate

: 1334493-36-5
benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(N,1-dimethyl-1H-imidazole-4-sulfonamido)acetamido)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / methanol / 3 h / 45 °C / Inert atmosphere; Molecular sieve

2: sodium cyanoborohydride / methanol / 20 °C / Inert atmosphere

3: dichlorotriphenylphosphorane / chloroform / 12 h / 60 °C / Inert atmosphere

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 0.17 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; dichloromethane; chloroform; water;
DOI:10.1016/j.bmcl.2011.06.056