2-{5-[tert-butoxycarbonyl(3,5-di-tert-butylbenzyl)amino]pentanoylamino}-3-phenylpropanoic acid methyl ester

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Chemical Name:2-{5-[tert-butoxycarbonyl(3,5-di-tert-butylbenzyl)amino]pentanoylamino}-3-phenylpropanoic acid methyl ester
CAS No.:518033-68-6
Molecular Formula:C₃₅H₅₂N₂O₅
Molecular Weight:580.808
Hs Code.:

Synonyms:2-{5-[tert-butoxycarbonyl(3,5-di-tert-butylbenzyl)amino]pentanoylamino}-3-phenylpropanoic acid methyl ester

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Chemical Property of 2-{5-[tert-butoxycarbonyl(3,5-di-tert-butylbenzyl)amino]pentanoylamino}-3-phenylpropanoic acid methyl ester

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Technology Process of 2-{5-[tert-butoxycarbonyl(3,5-di-tert-butylbenzyl)amino]pentanoylamino}-3-phenylpropanoic acid methyl ester

There total 5 articles about 2-{5-[tert-butoxycarbonyl(3,5-di-tert-butylbenzyl)amino]pentanoylamino}-3-phenylpropanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 518033-67-5
5-[tert-butoxycarbonyl-(3,5-di-tert-butylbenzyl)-amino]pentanoic acid

: 518033-68-6
2-{5-[tert-butoxycarbonyl(3,5-di-tert-butylbenzyl)amino]pentanoylamino}-3-phenylpropanoic acid methyl ester

Guidance literature:: 5-[tert-butoxycarbonyl-(3,5-di-tert-butylbenzyl)-amino]pentanoic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; for 0.333333h;

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride; With 1H-imidazole; In dichloromethane; at 20 ℃;
DOI:10.1021/jo026530q

Reference yield:

: 62938-08-3
3,5-di-tert-butylbenzyl bromide

: 518033-68-6
2-{5-[tert-butoxycarbonyl(3,5-di-tert-butylbenzyl)amino]pentanoylamino}-3-phenylpropanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide

1.2: 76 percent / dimethylformamide / 1 h

2.1: 88 percent / aq. HCl / 24 h / Heating

3.1: 100 percent / aq. NaOH / tetrahydrofuran / 1 h / 20 °C

4.1: CDI / CH₂Cl₂ / 0.33 h

4.2: 100 percent / imidazole / CH₂Cl₂ / 20 °C

With hydrogenchloride; sodium hydroxide; sodium hydride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo026530q

Reference yield:

: 675-20-7
piperidin-2-one

: 518033-68-6
2-{5-[tert-butoxycarbonyl(3,5-di-tert-butylbenzyl)amino]pentanoylamino}-3-phenylpropanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide

1.2: 76 percent / dimethylformamide / 1 h

2.1: 88 percent / aq. HCl / 24 h / Heating

3.1: 100 percent / aq. NaOH / tetrahydrofuran / 1 h / 20 °C

4.1: CDI / CH₂Cl₂ / 0.33 h

4.2: 100 percent / imidazole / CH₂Cl₂ / 20 °C

With hydrogenchloride; sodium hydroxide; sodium hydride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo026530q