(S)-1-(2-(tert-butyldimethylsilyloxy)ethyl)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one

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Chemical Name:(S)-1-(2-(tert-butyldimethylsilyloxy)ethyl)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one
CAS No.:1269647-67-7
Molecular Formula:C₃₄H₅₂N₈O₃Si₂
Molecular Weight:677.01
Hs Code.:

(S)-1-(2-(tert-butyldimethylsilyloxy)ethyl)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one

Synonyms:(S)-1-(2-(tert-butyldimethylsilyloxy)ethyl)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one

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Chemical Property of (S)-1-(2-(tert-butyldimethylsilyloxy)ethyl)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one

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Technology Process of (S)-1-(2-(tert-butyldimethylsilyloxy)ethyl)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one

There total 11 articles about (S)-1-(2-(tert-butyldimethylsilyloxy)ethyl)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1269647-65-5
(S)-5-isopropyl-1-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one

: 86864-60-0
2-(tert-butyldimethylsilyloxy)ethyl bromide

: 1269647-67-7
(S)-1-(2-(tert-butyldimethylsilyloxy)ethyl)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one

Guidance literature:: (S)-5-isopropyl-1-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one; With sodium hydride; at 0 ℃; for 0.166667h;

2-(tert-butyldimethylsilyloxy)ethyl bromide; at 0 - 20 ℃; for 2h;

Reference yield:

: 29274-24-6
5-chloropyrazolo[1,5-a]pyrimidine

: 1269647-67-7
(S)-1-(2-(tert-butyldimethylsilyloxy)ethyl)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 100 °C

3.1: triphenylphosphine; diisopropyl (E)-azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

4.1: methylhydrazine / methanol / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

6.1: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 80 °C / sealed tube; Inert atmosphere

7.1: sodium hydride / 0.17 h / 0 °C

7.2: 2 h / 0 - 20 °C

With N-Bromosuccinimide; sodium hydride; sodium carbonate; diisopropyl (E)-azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; methylhydrazine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 960613-96-1
3-bromo-5-chloro-pyrazolo[1,5-a]pyrimidine

: 1269647-67-7
(S)-1-(2-(tert-butyldimethylsilyloxy)ethyl)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 100 °C

2.1: triphenylphosphine; diisopropyl (E)-azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

3.1: methylhydrazine / methanol / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

5.1: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 80 °C / sealed tube; Inert atmosphere

6.1: sodium hydride / 0.17 h / 0 °C

6.2: 2 h / 0 - 20 °C

With sodium hydride; sodium carbonate; diisopropyl (E)-azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; methylhydrazine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;