N-benzyl-2-(4-(benzylamino)-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide

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Chemical Name:N-benzyl-2-(4-(benzylamino)-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide
CAS No.:1105690-22-9
Molecular Formula:C₂₄H₂₂N₄O₂S
Molecular Weight:430.53
Hs Code.:

Synonyms:N-benzyl-2-(4-(benzylamino)-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide

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Chemical Property of N-benzyl-2-(4-(benzylamino)-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide

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Technology Process of N-benzyl-2-(4-(benzylamino)-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide

There total 3 articles about N-benzyl-2-(4-(benzylamino)-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1105689-92-6
2-(4-amino-2-oxopyridin-1(2H)-yl)-N-benzyl-4-methylthiazole-5-carboxamide

: 100-52-7
benzaldehyde

: 1105690-22-9
N-benzyl-2-(4-(benzylamino)-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide

Guidance literature:: 2-(4-amino-2-oxopyridin-1(2H)-yl)-N-benzyl-4-methylthiazole-5-carboxamide; benzaldehyde; With trifluoroacetic acid; In chloroform; at 20 ℃; for 0.25h;

With triethylsilane; In chloroform; at 20 ℃; for 4h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 100-46-9
benzylamine

: 1105690-22-9
N-benzyl-2-(4-(benzylamino)-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: copper(l) iodide; potassium carbonate; 8-quinolinol / N,N-dimethyl-formamide / 80 °C

3: trifluoroacetic acid; trimethylsilan / chloroform

With copper(l) iodide; 8-quinolinol; trimethylsilan; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.12.035

Reference yield:

: 40003-41-6
2-bromo-4-methyl-thiazole-5-carboxylic acid

: 1105690-22-9
N-benzyl-2-(4-(benzylamino)-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: copper(l) iodide; potassium carbonate; 8-quinolinol / N,N-dimethyl-formamide / 80 °C

3: trifluoroacetic acid; trimethylsilan / chloroform

With copper(l) iodide; 8-quinolinol; trimethylsilan; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.12.035