9-<2',3'-dideoxy-2'(R)-2'-(1-piperidino)-5'-O-(MMTr)-β-D-glycero-pentofuranosyl>adenine

Base Information

Chemical Name:9-<2',3'-dideoxy-2'(R)-2'-(1-piperidino)-5'-O-(MMTr)-β-D-glycero-pentofuranosyl>adenine
CAS No.:119753-47-8
Molecular Formula:C₃₅H₃₈N₆O₃
Molecular Weight:590.725
Hs Code.:

Synonyms:9-<2',3'-dideoxy-2'(R)-2'-(1-piperidino)-5'-O-(MMTr)-β-D-glycero-pentofuranosyl>adenine

Suppliers and Price of 9-<2',3'-dideoxy-2'(R)-2'-(1-piperidino)-5'-O-(MMTr)-β-D-glycero-pentofuranosyl>adenine

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Chemical Property of 9-<2',3'-dideoxy-2'(R)-2'-(1-piperidino)-5'-O-(MMTr)-β-D-glycero-pentofuranosyl>adenine

Chemical Property:

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Technology Process of 9-<2',3'-dideoxy-2'(R)-2'-(1-piperidino)-5'-O-(MMTr)-β-D-glycero-pentofuranosyl>adenine

There total 7 articles about 9-<2',3'-dideoxy-2'(R)-2'-(1-piperidino)-5'-O-(MMTr)-β-D-glycero-pentofuranosyl>adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 119753-33-2
9-[(2R,3S,4R,5R)-5-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-3-piperidin-1-yl-4-(toluene-4-sulfonyl)-tetrahydro-furan-2-yl]-9H-purin-6-ylamine

: 119753-47-8
9-<2',3'-dideoxy-2'(R)-2'-(1-piperidino)-5'-O-(MMTr)-β-D-glycero-pentofuranosyl>adenine

Guidance literature:: With disodium hydrogenphosphate; sodium amalgam; In tetrahydrofuran; methanol; at 0 - 4 ℃; for 3h;
DOI:10.1016/S0040-4020(01)90111-5

Reference yield:

: 110-89-4
piperidine

: 119753-47-8
9-<2',3'-dideoxy-2'(R)-2'-(1-piperidino)-5'-O-(MMTr)-β-D-glycero-pentofuranosyl>adenine

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / tetrahydrofuran / 1.) 20 deg C, 2 d, 2.) 60 deg C, 1 d

2: 17 percent / 6percent sodium amalgam, disodium hydrogen phosphate / tetrahydrofuran; methanol / 3 h / 0 - 4 °C

With disodium hydrogenphosphate; sodium amalgam; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4020(01)90111-5

Reference yield:

: 2627-64-7
9-(2,3-anhydro-β-D-ribofuranosyl)adenine

: 119753-47-8
9-<2',3'-dideoxy-2'(R)-2'-(1-piperidino)-5'-O-(MMTr)-β-D-glycero-pentofuranosyl>adenine

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) sodium methoxide / 1.) MeOH, 20 deg C, 2.) reflux

2: 1.) chlorotrimethylsilane, pyridine / 1.) 20 deg C, 2 h, 2.) 3 h

3: 93 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 20 °C

4: 92 percent / pyridine / 24 h / 20 °C

5: 81 percent / methanesulfonyl chloride, pyridine / 24 h / 0 - 4 °C

6: 87 percent / tetrahydrofuran / 1.) 20 deg C, 2 d, 2.) 60 deg C, 1 d

7: 17 percent / 6percent sodium amalgam, disodium hydrogen phosphate / tetrahydrofuran; methanol / 3 h / 0 - 4 °C

With pyridine; disodium hydrogenphosphate; sodium amalgam; chloro-trimethyl-silane; sodium methylate; methanesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)90111-5