2627-64-7

Upstream product

• 669055-55-4 Benzyl-carbamic acid (4aR,6R,7R,7aS)-6-(6-amino-purin-9-yl)-2-oxo-tetrahydro-2λ⁴-furo[3,2-d][1,3,2]dioxathiin-7-yl ester 
• 58-61-7 adenosine 

Downstream Products

• 125084-70-0 9-<2,3-anhydro-5-O-<(tert-butyl)diphenylsilyl>-β-D-ribofuranosyl>adenine 
• 101856-99-9 6-N-5'-O-Bis<4-methoxytriphenylmethyl>-2',3'-anhydroadenosine 
• 73-03-0 cordycepin 
• 20535-16-4 (2R,3S,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol 
• 20187-82-0 9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine 
• 524-69-6 adenine xyloside 
• 182126-72-3 Benzyl-carbamic acid (1R,2R,4R,5R)-4-(6-amino-purin-9-yl)-3,6-dioxa-bicyclo[3.1.0]hex-2-ylmethyl ester 
• 134100-24-6 9-[5-O-(tert-butyldimethylsilyl)-3-deoxy-3-C-phenylselenenyl-β-D-xylofuranosyl]adenine 
• 440099-55-8 9-[5-O-(tert-butyldimethylsilyl)-3-deoxy-3-C-phenylthio-β-D-xylofuranosyl]adenine 
• 440099-56-9 9-[5-O-(tert-butyldimethylsilyl)-3-deoxy-2-O-methanesulfonyl-3-C-phenylthio-β-D-xylofuranosyl]adenine 
• 440099-59-2 9-[5-O-(tert-butyldimethylsilyl)-3-deoxy-3-C-phenylthio-β-D-xylofuranosyl]-N6-pivaloyladenine 
• 440099-60-5 9-[3-C-benzenesulfonyl-5-O-(tert-butyldimethylsilyl)-3-deoxy-β-D-xylofuranosyl]-N6-pivaloyladenine 
• 67313-10-4 9-[3-(benzylamino)-3-deoxy-β-D-ribofuranosyl]adenine 
• 2504-55-4 3'-amino-3'-deoxyadenosine 

Relevant academic research and scientific papers

NEW 2' AND/OR 5' AMINO-ACID ESTER PHOSPHORAMIDATE 3'-DEOXY ADENOSINE DERIVATIVES AS ANTI-CANCER COMPOUNDS

The present invention relates to chemical compounds, the compounds for use in a method of treatment, particularly in a method of prophylaxis or treatment for cancer, a process for preparation of the compounds and pharmaceutical compositions comprising the compounds. The compounds may, in particular, be useful in the treatment of leukaemia, lymphoma and/or solid tumours inhomo sapiens. The compounds are derivatives of cordycepin (3'-deoxyadenosine) having a 2' and/or 5'- amino-acid ester phosphoramidate moeity.

A new protecting group '3′,5′-O-sulfinyl' for xylo-nucleosides. A simple and efficient synthesis of 3′-amino-3′-deoxyadenosine (a puromycin intermediate), 2,2′-anhydro-pyrimidine nucleosides and 2′,3′-anhydro-adenosine

We developed a new protecting group, the cyclic sulfite for the protection of the 3′,5′-dihydroxy group of nucleosides. Seven cyclic sulfites, 4a-c, 5a-b, and 6a-b were prepared in high yields from the corresponding xylo-uridines 1 and 2, and xylo-adenosines 3 with thionyl chloride, respectively. Synthesis of the puromycin intermediate 8 was carried out by deprotection of the sulfite moiety through an intramolecular cyclization of the 2′-α-carbamate 7.