tert-butyl 4-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)piperazine-1-carboxylate
CAS No.:1608469-59-5
Molecular Formula:C₂₃H₂₈F₂N₂O₆S
Molecular Weight:498.548
Hs Code.:

Synonyms:tert-butyl 4-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)piperazine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)piperazine-1-carboxylate

There total 4 articles about tert-butyl 4-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1286715-98-7
sodium 3-(difluoromethoxy)benzenesulfinate

: 1608469-58-4
tert-butyl 4-(5-iodo-2-methoxyphenyl)piperazine-1-carboxylate

: 1608469-59-5
tert-butyl 4-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)piperazine-1-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl-ammonium chloride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 80 ℃; for 8h; Inert atmosphere;

Reference yield:

: 177488-99-2
tert-butyl 4-(2-methoxy-5-nitrophenyl)piperazine-1-carboxylate

: 1608469-59-5
tert-butyl 4-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; ammonium formate / ethanol; water / 1 h / 80 °C

2.1: trifluoroacetic acid / dichloromethane / 0 °C

2.2: 0.17 h / 0 °C

2.3: 2 h / 0 - 5 °C

3.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl-ammonium chloride / toluene / 8 h / 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; tetrabutyl-ammonium chloride; ammonium formate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In ethanol; dichloromethane; water; toluene;

Reference yield:

: 148546-91-2
tert-butyl 4-(5-amino-2-methoxyphenyl)piperazine-1-carboxylate

: 1608469-59-5
tert-butyl 4-(5-(3-(difluoromethoxy)phenylsulfonyl)-2-methoxyphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 0 °C

1.2: 0.17 h / 0 °C

1.3: 2 h / 0 - 5 °C

2.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl-ammonium chloride / toluene / 8 h / 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl-ammonium chloride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In dichloromethane; toluene;