(R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cyclooctylpiperidine-2-carboxamide

Base Information

Chemical Name:(R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cyclooctylpiperidine-2-carboxamide
CAS No.:1472657-17-2
Molecular Formula:C₂₁H₃₁ClN₂O₃S
Molecular Weight:427.008
Hs Code.:

Synonyms:(R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cyclooctylpiperidine-2-carboxamide

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Chemical Property of (R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cyclooctylpiperidine-2-carboxamide

Chemical Property:

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Technology Process of (R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cyclooctylpiperidine-2-carboxamide

There total 3 articles about (R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cyclooctylpiperidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80563-86-6
3-chloro-2-methylbenzenesulfonyl chloride

: 1472657-17-2
(R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cyclooctylpiperidine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 8 h / 20 °C / Inert atmosphere

2: sodium hydroxide / water; methanol / 5 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 6 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; dichloromethane; water;
DOI:10.1002/cmdc.201300022

Reference yield:

: 1472657-63-8
C₁₃H₁₆ClNO₄S

: 5452-37-9
cyclooctylamine

: 1472657-17-2
(R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cyclooctylpiperidine-2-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1002/cmdc.201300022

Reference yield:

: 1472657-62-7
(R)-methyl 1-(3-chloro-2-methylphenylsulfonyl)-N-cyclohexylpiperidine-2-carboxylate

: 1472657-17-2
(R)-1-(3-chloro-2-methylphenylsulfonyl)-N-cyclooctylpiperidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; methanol / 5 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 6 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; dichloromethane; water;
DOI:10.1002/cmdc.201300022