(1R,2R)-2-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2-methyl-cyclohexanol

Base Information

• Chemical Name: (1R,2R)-2-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2-methyl-cyclohexanol
• CAS No.: 194808-78-1
• Molecular Formula: C₁₆H₃₄O₂Si
• Molecular Weight: 286.53

Synonyms:(1R,2R)-2-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2-methyl-cyclohexanol

Chemical Property of (1R,2R)-2-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2-methyl-cyclohexanol

Chemical Property:

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Technology Process of (1R,2R)-2-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2-methyl-cyclohexanol

There total 2 articles about (1R,2R)-2-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2-methyl-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-(+)-2-(2'-carbomethoxyethyl)-2-methylcyclohexanone (53068-89-6,112898-44-9,150927-14-3,94089-47-1) → (1R,2R)-2-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2-methyl-cyclohexanol (194808-78-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / LiAlH₄ / diethyl ether / 3 h / Ambient temperature

2: Et₃N, 4-DMAP / CH₂Cl₂ / Ambient temperature

With dmap; lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1139/v97-077

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) + (1R,2R)-2-(3-Hydroxy-propyl)-2-methyl-cyclohexanol (160024-17-9) → (1R,2R)-2-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2-methyl-cyclohexanol (194808-78-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; Yield given; Ambient temperature;

DOI:10.1139/v97-077

Reference yield: 66.0%

(1R,2R)-2-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-2-methyl-cyclohexanol (194808-78-1) → tert-Butyl-dimethyl-[3-((R)-1-methyl-cyclohex-2-enyl)-propoxy]-silane (194808-79-2)

Guidance literature:

With 4 A molecular sieve; trichlorophosphate; In pyridine; Ambient temperature;

DOI:10.1139/v97-077

upstream raw materials:

tert-butyldimethylsilyl chloride

(1R,2R)-2-(3-Hydroxy-propyl)-2-methyl-cyclohexanol

(R)-(+)-2-(2'-carbomethoxyethyl)-2-methylcyclohexanone

Downstream raw materials:

tert-Butyl-dimethyl-[3-((R)-1-methyl-cyclohex-2-enyl)-propoxy]-silane

(S)-4-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-methyl-cyclohex-2-enone

(1R,4S)-4-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-methyl-cyclohex-2-enol

(1S,4S)-4-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-methyl-cyclohex-2-enol

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