(2R,3S,5R)-5-Biphenyl-4-yl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol

Base Information

Chemical Name:(2R,3S,5R)-5-Biphenyl-4-yl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol
CAS No.:851787-54-7
Molecular Formula:C₃₈H₃₆O₅
Molecular Weight:572.701
Hs Code.:

Synonyms:(2R,3S,5R)-5-Biphenyl-4-yl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol

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Chemical Property of (2R,3S,5R)-5-Biphenyl-4-yl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol

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Technology Process of (2R,3S,5R)-5-Biphenyl-4-yl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol

There total 10 articles about (2R,3S,5R)-5-Biphenyl-4-yl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 851787-53-6
(2R,3S,5R)-5-Biphenyl-4-yl-2-hydroxymethyl-tetrahydro-furan-3-ol

: 851787-54-7
(2R,3S,5R)-5-Biphenyl-4-yl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol

Guidance literature:: With pyridine; at 20 ℃; for 6h;
DOI:10.1002/chem.200400858

Reference yield:

: 3315-91-1
4-biphenylylmagnesium bromide

: 851787-54-7
(2R,3S,5R)-5-Biphenyl-4-yl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuI / tetrahydrofuran / 0.08 h / 0 °C

1.2: tetrahydrofuran / 0.5 h / 25 °C

1.3: NaOMe; MeOH / 4 h

2.1: 4-(dimethylamino)pyridine; iPr₂NEt; pyridine / CH₂Cl₂ / 8 h

With pyridine; dmap; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.200219972

Reference yield:

: (2S,3R,4S,5R)-2-Biphenyl-4-yl-5-hydroxymethyl-tetrahydro-furan-3,4-diol

: 851787-54-7
(2R,3S,5R)-5-Biphenyl-4-yl-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 761 mg / pyridine / 5 h / 20 °C

2: 84 percent / acetonitrile / 18 h / 20 °C

3: 78 percent / Bu₃SnH; AIBN / toluene / 2 h / 80 °C

4: 98 percent / NEt₃*3HF / tetrahydrofuran / 15 h / 20 °C

5: 85 percent / pyridine / 6 h / 20 °C

With pyridine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; toluene; acetonitrile;
DOI:10.1002/chem.200400858