(2S)-2-Hydroxy-3,3-dimethylbutanoic acid homopolymer

Base Information

• Chemical Name: (2S)-2-Hydroxy-3,3-dimethylbutanoic acid homopolymer
• CAS No.: 851866-86-9
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.159
• Mol file: 851866-86-9.mol

Synonyms:(2S)-2-Hydroxy-3,3-dimethylbutanoic acid homopolymer

Chemical Property of (2S)-2-Hydroxy-3,3-dimethylbutanoic acid homopolymer

Chemical Property:

• PSA: 57.53000
• LogP: 0.47800

Purity/Quality:

99.3% ^*data from raw suppliers

(S)-2-Hydroxy-3,3-dimethylbutanoicacidhomopolymer 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S)-2-Hydroxy-3,3-dimethylbutanoic acid homopolymer

There total 55 articles about (2S)-2-Hydroxy-3,3-dimethylbutanoic acid homopolymer which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-hydroxy-3,3-dimethylbutyronitrile (33350-17-3) → 2-hydroxy-3,3-dimethylbutanoic acid (4026-20-4,851866-86-9)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 20h; Reflux;

DOI:10.1016/j.tet.2009.01.117

Reference yield: 95.0%

1,1-dichloro-3,3-dimethylbutan-2-one (22591-21-5) → 2-hydroxy-3,3-dimethylbutanoic acid (4026-20-4,851866-86-9)

Guidance literature:

With sodium hydroxide; at 50 - 70 ℃; for 1h;

Reference yield: 93.0%

phosphoric acid 1,1-dicyano-2,2-dimethyl-propyl ester diethyl ester → 2-hydroxy-3,3-dimethylbutanoic acid (4026-20-4,851866-86-9)

Guidance literature:

With hydrogenchloride; for 24h; Heating;

DOI:10.1016/S0040-4039(98)02099-1

upstream raw materials:

3,3-dimethyl-butan-2-one

1-hydroxy-3,3-dimethylbutan-2-one

2-bromo-2-tert-butyl acetic acid

1,1-dibromo-3,3-dimethylbutan-2-one

Downstream raw materials:

(3S)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-2-[(2R)-2-hydroxy-3,3-dimethylbutanoyl]pyrazolidine-3-carboxamide

(3S)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-2-[(2R)-2-hydroxy-3,3-dimethylbutanoyl]isoxazolidine-3-carboxamide

(1S,5R)-N-[[5-chloro-2-(tetrazol-1-yl)phenyl]methyl]-2-[(2R)-2-hydroxy-3,3-dimethylbutanoyl]-2-azabicyclo[3.1.0]hexane-1-carboxamide

(1R,2S,5S)-3-((R)-2-hydroxy-3,3-dimethylbutyryl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide

Refernces

• 1、 Horn, Alexander,Kazmaier, Uli. "Stereoselective Modification of N-(α-Hydroxyacyl)-glycinesters via Palladium-Catalyzed Allylic Alkylation". supporting information. p. 4595 - 4599. Retrieved 2019/06/27.
• 2、 Guyon, Hélène,Boussonnière, Anne,Castanet, Anne-Sophie. "Readily Accessible 1,2-Amino Ether Ligands for Enantioselective Intramolecular Carbolithiation". . p. 4949 - 4957. Retrieved 2017/05/12.