methyl 3-[ethyl(piperidin-4-yl)amino]-2-methyl-5-(trifluoromethyl)benzoate trifluoroacetate

Base Information

Chemical Name:methyl 3-[ethyl(piperidin-4-yl)amino]-2-methyl-5-(trifluoromethyl)benzoate trifluoroacetate
CAS No.:1403595-15-2
Molecular Formula:C₂HF₃O₂*C₁₇H₂₃F₃N₂O₂
Molecular Weight:458.401
Hs Code.:

Synonyms:methyl 3-[ethyl(piperidin-4-yl)amino]-2-methyl-5-(trifluoromethyl)benzoate trifluoroacetate

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Chemical Property of methyl 3-[ethyl(piperidin-4-yl)amino]-2-methyl-5-(trifluoromethyl)benzoate trifluoroacetate

Chemical Property:

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Technology Process of methyl 3-[ethyl(piperidin-4-yl)amino]-2-methyl-5-(trifluoromethyl)benzoate trifluoroacetate

There total 4 articles about methyl 3-[ethyl(piperidin-4-yl)amino]-2-methyl-5-(trifluoromethyl)benzoate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403595-13-0
tert-butyl-4-{ethyl[3-(methoxycarbonyl)-2-methyl-5-(trifluoromethyl)phenyl]amino}piperidine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1403595-15-2
methyl 3-[ethyl(piperidin-4-yl)amino]-2-methyl-5-(trifluoromethyl)benzoate trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 13055-63-5
2-methyl-5-(trifluoromethyl)benzoic acid

: 1403595-15-2
methyl 3-[ethyl(piperidin-4-yl)amino]-2-methyl-5-(trifluoromethyl)benzoate trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

2: hydrogen / palladium(II) hydroxide / methanol / 3 h

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 h / 23 °C

4: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 24 h / 23 °C

5: dichloromethane / 18 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; palladium(II) hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1396780-64-5
methyl 2-methyl-3-nitro-5-(trifluoromethyl)benzoate

: 1403595-15-2
methyl 3-[ethyl(piperidin-4-yl)amino]-2-methyl-5-(trifluoromethyl)benzoate trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium(II) hydroxide / methanol / 3 h

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 h / 23 °C

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 24 h / 23 °C

4: dichloromethane / 18 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; palladium(II) hydroxide; In methanol; dichloromethane;