methyl 3-{ethyl[1-(propan-2-yl)piperidin-4-yl]amino}-2-methyl-5-(trifluoromethyl)benzoate

Base Information

Chemical Name:methyl 3-{ethyl[1-(propan-2-yl)piperidin-4-yl]amino}-2-methyl-5-(trifluoromethyl)benzoate
CAS No.:1403595-17-4
Molecular Formula:C₂₀H₂₉F₃N₂O₂
Molecular Weight:386.458
Hs Code.:

Synonyms:methyl 3-{ethyl[1-(propan-2-yl)piperidin-4-yl]amino}-2-methyl-5-(trifluoromethyl)benzoate

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Chemical Property of methyl 3-{ethyl[1-(propan-2-yl)piperidin-4-yl]amino}-2-methyl-5-(trifluoromethyl)benzoate

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Technology Process of methyl 3-{ethyl[1-(propan-2-yl)piperidin-4-yl]amino}-2-methyl-5-(trifluoromethyl)benzoate

There total 4 articles about methyl 3-{ethyl[1-(propan-2-yl)piperidin-4-yl]amino}-2-methyl-5-(trifluoromethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403595-15-2
methyl 3-[ethyl(piperidin-4-yl)amino]-2-methyl-5-(trifluoromethyl)benzoate trifluoroacetate

: 67-64-1
acetone

: 1403595-17-4
methyl 3-{ethyl[1-(propan-2-yl)piperidin-4-yl]amino}-2-methyl-5-(trifluoromethyl)benzoate

Guidance literature:: methyl 3-[ethyl(piperidin-4-yl)amino]-2-methyl-5-(trifluoromethyl)benzoate trifluoroacetate; acetone; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 23 ℃; for 144h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 13055-63-5
2-methyl-5-(trifluoromethyl)benzoic acid

: 1403595-17-4
methyl 3-{ethyl[1-(propan-2-yl)piperidin-4-yl]amino}-2-methyl-5-(trifluoromethyl)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

2: hydrogen / palladium(II) hydroxide / methanol / 3 h

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 h / 23 °C

4: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 24 h / 23 °C

5: dichloromethane / 18 h / 20 °C

6: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 144 h / 23 °C

With hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; palladium(II) hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1396780-64-5
methyl 2-methyl-3-nitro-5-(trifluoromethyl)benzoate

: 1403595-17-4
methyl 3-{ethyl[1-(propan-2-yl)piperidin-4-yl]amino}-2-methyl-5-(trifluoromethyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium(II) hydroxide / methanol / 3 h

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 h / 23 °C

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 24 h / 23 °C

4: dichloromethane / 18 h / 20 °C

5: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 144 h / 23 °C

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; palladium(II) hydroxide; In methanol; dichloromethane;