(2R,2'S,4'S)-2-[2-(tert-butyl)-4-(3-methoxybenzyl)-5-oxo-1,3-dioxolan-4-yl]-3-(3-methoxyphenyl)propanoic acid

Base Information

Chemical Name:(2R,2'S,4'S)-2-[2-(tert-butyl)-4-(3-methoxybenzyl)-5-oxo-1,3-dioxolan-4-yl]-3-(3-methoxyphenyl)propanoic acid
CAS No.:363139-57-5
Molecular Formula:C₂₅H₃₀O₇
Molecular Weight:442.509
Hs Code.:

Synonyms:(2R,2'S,4'S)-2-[2-(tert-butyl)-4-(3-methoxybenzyl)-5-oxo-1,3-dioxolan-4-yl]-3-(3-methoxyphenyl)propanoic acid

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Chemical Property of (2R,2'S,4'S)-2-[2-(tert-butyl)-4-(3-methoxybenzyl)-5-oxo-1,3-dioxolan-4-yl]-3-(3-methoxyphenyl)propanoic acid

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Technology Process of (2R,2'S,4'S)-2-[2-(tert-butyl)-4-(3-methoxybenzyl)-5-oxo-1,3-dioxolan-4-yl]-3-(3-methoxyphenyl)propanoic acid

There total 3 articles about (2R,2'S,4'S)-2-[2-(tert-butyl)-4-(3-methoxybenzyl)-5-oxo-1,3-dioxolan-4-yl]-3-(3-methoxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 874-98-6
1-bromomethyl-3-methoxybenzene

: (4'S)-2-[2-(tert-butyl)-5-oxo-1,3-dioxolan-4-yl]-3-(3-methpxyphenyl)propionic acid

: 363139-57-5
(2R,2'S,4'S)-2-[2-(tert-butyl)-4-(3-methoxybenzyl)-5-oxo-1,3-dioxolan-4-yl]-3-(3-methoxyphenyl)propanoic acid

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1002/hlca.200290007

Reference yield: 48.0%

: 630-19-3
pivalaldehyde

: 874-98-6
1-bromomethyl-3-methoxybenzene

: 363139-49-5
(2R,3S)-2-Hydroxy-3-(3-methoxy-benzyl)-succinic acid diisopropyl ester

: 363139-57-5
(2R,2'S,4'S)-2-[2-(tert-butyl)-4-(3-methoxybenzyl)-5-oxo-1,3-dioxolan-4-yl]-3-(3-methoxyphenyl)propanoic acid

Guidance literature:: (2R,3S)-2-Hydroxy-3-(3-methoxy-benzyl)-succinic acid diisopropyl ester; With potassium hydroxide; In methanol;

pivalaldehyde; With toluene-4-sulfonic acid; In benzene; Heating;

1-bromomethyl-3-methoxybenzene; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(01)00907-8

Reference yield:

: 874-98-6
1-bromomethyl-3-methoxybenzene

: 363139-57-5
(2R,2'S,4'S)-2-[2-(tert-butyl)-4-(3-methoxybenzyl)-5-oxo-1,3-dioxolan-4-yl]-3-(3-methoxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 68 percent / LiHMDS

2.1: KOH / methanol

2.2: p-TsOH / benzene / Heating

2.3: 48 percent / LiHMDS / tetrahydrofuran / -78 °C

With potassium hydroxide; lithium hexamethyldisilazane; In methanol;
DOI:10.1016/S0040-4039(01)00907-8