[3-(tert-butyldiphenylsiloxy)-4-hexylphenyl]-(6-chloro-9H-purin-2-yl)-amine

Base Information

Chemical Name:[3-(tert-butyldiphenylsiloxy)-4-hexylphenyl]-(6-chloro-9H-purin-2-yl)-amine
CAS No.:1252577-07-3
Molecular Formula:C₃₃H₃₈ClN₅OSi
Molecular Weight:584.236
Hs Code.:

Synonyms:[3-(tert-butyldiphenylsiloxy)-4-hexylphenyl]-(6-chloro-9H-purin-2-yl)-amine

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Chemical Property of [3-(tert-butyldiphenylsiloxy)-4-hexylphenyl]-(6-chloro-9H-purin-2-yl)-amine

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Technology Process of [3-(tert-butyldiphenylsiloxy)-4-hexylphenyl]-(6-chloro-9H-purin-2-yl)-amine

There total 8 articles about [3-(tert-butyldiphenylsiloxy)-4-hexylphenyl]-(6-chloro-9H-purin-2-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 2-[3-(tert-butyldiphenylsiloxy)-4-hexylphenylamino]-1,4,5,9-tetrahydropurin-6-one

: 1252577-07-3
[3-(tert-butyldiphenylsiloxy)-4-hexylphenyl]-(6-chloro-9H-purin-2-yl)-amine

Guidance literature:: 2-[3-(tert-butyldiphenylsiloxy)-4-hexylphenylamino]-1,4,5,9-tetrahydropurin-6-one; With tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; trichlorophosphate; In acetonitrile; at 110 ℃; for 8.5h;

With sodium acetate; In acetonitrile; at 0 ℃; for 15.25h;
DOI:10.1016/j.ijpharm.2010.06.036

Reference yield:

: 1252577-05-1
3-(tert-butyldiphenylsiloxy)-4-hexylphenylamine

: 1252577-07-3
[3-(tert-butyldiphenylsiloxy)-4-hexylphenyl]-(6-chloro-9H-purin-2-yl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethyl methyl ether; water / 16 h / 125 °C

2.1: tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 8.5 h / 110 °C

2.2: 15.25 h / 0 °C

With tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; trichlorophosphate; In ethyl methyl ether; water; acetonitrile;
DOI:10.1016/j.ijpharm.2010.06.036

Reference yield:

: C₁₄H₁₉NO₃

: 1252577-07-3
[3-(tert-butyldiphenylsiloxy)-4-hexylphenyl]-(6-chloro-9H-purin-2-yl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium on activated charcoal; methanesulfonic acid; hydrogen; acetic acid / ethanol; ethyl acetate

2.1: potassium hydroxide / methanol; water / 3.5 h / 100 °C

3.1: pyridine; dmap / 144 h / Heating

4.1: ethyl methyl ether; water / 16 h / 125 °C

5.1: tetrabutyl-ammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 8.5 h / 110 °C

5.2: 15.25 h / 0 °C

With pyridine; dmap; methanesulfonic acid; palladium on activated charcoal; tetrabutyl-ammonium chloride; hydrogen; acetic acid; N,N-dimethyl-aniline; potassium hydroxide; trichlorophosphate; In methanol; ethanol; ethyl methyl ether; water; ethyl acetate; acetonitrile;
DOI:10.1016/j.ijpharm.2010.06.036