2-Bromohypoxanthine

Base Information

• Chemical Name: 2-Bromohypoxanthine
• CAS No.: 87781-93-9
• Molecular Formula: C5H3BrN4O
• Molecular Weight: 215.009
• Hs Code.: 2933990090
• Mol file: 87781-93-9.mol

Synonyms:6H-Purin-6-one,2-bromo-1,7-dihydro- (9CI);Hypoxanthine, 2-bromo- (7CI);2-Bromohypoxanthine;NSC 62629;2-Bromo-3,7-dihydropurin-6-one;

Chemical Property of 2-Bromohypoxanthine

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 1.36E-11mmHg at 25°C
• Melting Point: >350 °C
• Refractive Index: 1.958
• Boiling Point: 536.7 °C at 760 mmHg
• PKA: 7.95±0.20(Predicted)
• Flash Point: 278.4 °C
• PSA: 74.43000
• Density: 2.54 g/cm³
• LogP: 0.40870
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

2-Bromohypoxanthine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-Bromohypoxanthine

There total 4 articles about 2-Bromohypoxanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-mercapto-1,9-dihydro-6H-purin-6-one (2487-40-3) → 2-bromo-1,9-dihydro-6H-purin-6-one (87781-93-9)

Guidance literature:

With hydrogen bromide; bromine; In methanol; at 5 ℃;

DOI:10.1021/tx980160c

Reference yield: 53.5%

6-hydroxy-2-mercaptopurine (2487-40-3) → 2-bromo-6-hydroxypurine (87781-93-9)

Guidance literature:

With bromine; In methanol; hydrogen bromide; at 0 ℃; for 4h;

DOI:10.1021/tx700323k

Reference yield: 46.0%

aqueous sodium sulfite + 6R-methoxy-2,2-dimethyl-tetrahydro-(3AR,6AR)-furo[3,4-d][1,3]dioxol-4R-yl)-methanol + D-ribose (50-69-1) + 2,2-dimethoxy-propane (77-76-9) → 2-bromohypoxanthine (87781-93-9)

Guidance literature:

With potassium bromide; perchloric acid; cyfluthrin; nitrogen; sodium hydrogencarbonate; sodium carbonate; In methanol; sodium hypochlorite; water; ethyl acetate; acetone;

upstream raw materials:

6-hydroxy-2-mercaptopurine

2-mercapto-1,9-dihydro-6H-purin-6-one

D-ribose

2,2-dimethoxy-propane

Downstream raw materials:

N²-(4-hydroxyphenyl)guanine

2-(1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-6-ol

(2S)-2-[(6-chloro-9H-purin-2-yl)amino]-3-phenyl-1-propanol

(2S)-2-[(6-amino-9H-purin-2-yl)amino]-3-phenyl-1-propanol