trans-5-hydroxy-2-(1-methyl-2-phenoxyethyl)amino-1,2,3,4-tetrahydronaphthalen-1-ol

Base Information

Chemical Name:trans-5-hydroxy-2-(1-methyl-2-phenoxyethyl)amino-1,2,3,4-tetrahydronaphthalen-1-ol
CAS No.:88627-55-8
Molecular Formula:C₄H₄O₄*C₁₉H₂₃NO₃
Molecular Weight:429.47
Hs Code.:

Synonyms:trans-5-hydroxy-2-(1-methyl-2-phenoxyethyl)amino-1,2,3,4-tetrahydronaphthalen-1-ol

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Chemical Property of trans-5-hydroxy-2-(1-methyl-2-phenoxyethyl)amino-1,2,3,4-tetrahydronaphthalen-1-ol

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Technology Process of trans-5-hydroxy-2-(1-methyl-2-phenoxyethyl)amino-1,2,3,4-tetrahydronaphthalen-1-ol

There total 4 articles about trans-5-hydroxy-2-(1-methyl-2-phenoxyethyl)amino-1,2,3,4-tetrahydronaphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 88627-60-5
trans-6-benzyloxy-2-(1-methyl-2-phenoxyethyl)-amino-1,2,3,4-tetrahydronaphthalen-1-ol

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 88627-55-8
trans-5-hydroxy-2-(1-methyl-2-phenoxyethyl)amino-1,2,3,4-tetrahydronaphthalen-1-ol

Guidance literature:: With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; diethyl ether; Ambient temperature;
DOI:10.1248/cpb.31.2329

Reference yield:

: 621-87-4
3-phenoxy-2-propanone

: 88627-55-8
trans-5-hydroxy-2-(1-methyl-2-phenoxyethyl)amino-1,2,3,4-tetrahydronaphthalen-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / 1.) NaBH₃CN / methanol; ethanol / 5 °C

2: 86 percent / 1.) NaHCO₃; 2.) hydrogen / 2.) 10percent Pd-C / methanol; diethyl ether / Ambient temperature

With hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; diethyl ether; ethanol;
DOI:10.1248/cpb.31.2329

Reference yield:

: 66361-76-0
2-Amino-6-benzyloxy-3,4-dihydro-2H-naphthalen-1-one; hydrochloride

: 88627-55-8
trans-5-hydroxy-2-(1-methyl-2-phenoxyethyl)amino-1,2,3,4-tetrahydronaphthalen-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / 1.) NaBH₄; 2.) 20percent HCl/EtOH / methanol / 0.5 h / Ambient temperature

2: 70 percent / 1.) NaBH₃CN / methanol; ethanol / 5 °C

3: 86 percent / 1.) NaHCO₃; 2.) hydrogen / 2.) 10percent Pd-C / methanol; diethyl ether / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; ethanol; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; diethyl ether; ethanol;
DOI:10.1248/cpb.31.2329