1-Ethoxymethyl-6-(hydroxy-phenyl-methyl)-5-isopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Base Information

Chemical Name:1-Ethoxymethyl-6-(hydroxy-phenyl-methyl)-5-isopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one
CAS No.:1026065-34-8
Molecular Formula:C₁₇H₂₂N₂O₃S
Molecular Weight:334.439
Hs Code.:

Synonyms:1-Ethoxymethyl-6-(hydroxy-phenyl-methyl)-5-isopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

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Chemical Property of 1-Ethoxymethyl-6-(hydroxy-phenyl-methyl)-5-isopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

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Technology Process of 1-Ethoxymethyl-6-(hydroxy-phenyl-methyl)-5-isopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

There total 1 articles about 1-Ethoxymethyl-6-(hydroxy-phenyl-methyl)-5-isopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-52-7
benzaldehyde

: 144410-21-9
1-(ethoxymethyl)-5-isopropyl-2-thiouracil

: 1026065-34-8
1-Ethoxymethyl-6-(hydroxy-phenyl-methyl)-5-isopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Guidance literature:: With lithium diisopropyl amide; Multistep reaction;
DOI:10.1080/15257779508012431

Reference yield:

: 1026065-34-8
1-Ethoxymethyl-6-(hydroxy-phenyl-methyl)-5-isopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

: 6-benzyl-1-butyl-5-isopropyluracil

Guidance literature:: Multi-step reaction with 7 steps

1: 35percent H₂O₂, 1N aq. NaOH / 1 h / Ambient temperature

2: pyridine / 12 h / Ambient temperature

3: 85 percent / H₂, aq. AcOH / 10percent Pd/C / dioxane / 15 h / 60 °C / 760 Torr

4: K₂CO₃ / acetonitrile / 2 h / Heating

5: 90percent aq. TFA / 1 h / Heating

6: K₂CO₃ / dimethylsulfoxide / 0.33 h / 80 °C

7: Zn, AcOH / 14 h / Heating

With pyridine; sodium hydroxide; hydrogen; dihydrogen peroxide; potassium carbonate; acetic acid; trifluoroacetic acid; zinc; palladium on activated charcoal; In 1,4-dioxane; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm00015a008

Reference yield:

: 1026065-34-8
1-Ethoxymethyl-6-(hydroxy-phenyl-methyl)-5-isopropyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

: 6-benzyl-5-isopropyl-1-(2-methoxyethyl)uracil

Guidance literature:: Multi-step reaction with 7 steps

1: 35percent H₂O₂, 1N aq. NaOH / 1 h / Ambient temperature

2: pyridine / 12 h / Ambient temperature

3: 85 percent / H₂, aq. AcOH / 10percent Pd/C / dioxane / 15 h / 60 °C / 760 Torr

4: K₂CO₃ / acetonitrile / 2 h / Heating

5: 90percent aq. TFA / 1 h / Heating

6: K₂CO₃ / dimethylsulfoxide / 0.33 h / 80 °C

7: Zn, AcOH / 14 h / Heating

With pyridine; sodium hydroxide; hydrogen; dihydrogen peroxide; potassium carbonate; acetic acid; trifluoroacetic acid; zinc; palladium on activated charcoal; In 1,4-dioxane; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm00015a008