4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(trifluoromethyl)alaninate

Base Information

Chemical Name:4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(trifluoromethyl)alaninate
CAS No.:515871-92-8
Molecular Formula:C₂₉H₃₅F₃N₄O₈
Molecular Weight:624.614
Hs Code.:

Synonyms:4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(trifluoromethyl)alaninate

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Chemical Property of 4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(trifluoromethyl)alaninate

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Technology Process of 4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(trifluoromethyl)alaninate

There total 3 articles about 4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(trifluoromethyl)alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 139520-43-7
2-{[(benzyloxy)carbonyl]amino}-3,3,3-trifluoro-2-methylpropanoic acid

: 226087-02-1
4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenol

: 515871-92-8
4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(trifluoromethyl)alaninate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jo020613p

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 515871-92-8
4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(trifluoromethyl)alaninate

Guidance literature:: Multi-step reaction with 3 steps

1: dioxane / 24 h / 20 °C / pH 7.0

2: tetrahydrofuran / 20 °C

3: 93 percent / TBTU; DIEA / dimethylformamide / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jo020613p

Reference yield:

: 322474-21-5
N,N'-bis-Boc-S-methyl-isothiourea

: 515871-92-8
4-[N',N''-bis(tert-butyloxycarbonyl)guanidino]phenyl N-(benzyloxycarbonyl)-α-(trifluoromethyl)alaninate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C

2: 93 percent / TBTU; DIEA / dimethylformamide / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo020613p