7-Benzyl-8-hydroxymethyl-1,4-dioxa-7-aza-spiro[4.5]decane-8-carbonitrile

Base Information

Chemical Name:7-Benzyl-8-hydroxymethyl-1,4-dioxa-7-aza-spiro[4.5]decane-8-carbonitrile
CAS No.:132462-35-2
Molecular Formula:C₁₆H₂₀N₂O₃
Molecular Weight:288.346
Hs Code.:

Synonyms:7-Benzyl-8-hydroxymethyl-1,4-dioxa-7-aza-spiro[4.5]decane-8-carbonitrile

Suppliers and Price of 7-Benzyl-8-hydroxymethyl-1,4-dioxa-7-aza-spiro[4.5]decane-8-carbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-Benzyl-8-hydroxymethyl-1,4-dioxa-7-aza-spiro[4.5]decane-8-carbonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7-Benzyl-8-hydroxymethyl-1,4-dioxa-7-aza-spiro[4.5]decane-8-carbonitrile

There total 5 articles about 7-Benzyl-8-hydroxymethyl-1,4-dioxa-7-aza-spiro[4.5]decane-8-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 132462-34-1
1-Benzyl-5,5-(ethylenedioxy)-2-(2-ethoxycarbonyl)-2-piperidinecarbonitrile

: 132462-37-4
1-Benzyl-5,5-(ethylenedioxy)-2-piperidinemethanol

: 132462-35-2
7-Benzyl-8-hydroxymethyl-1,4-dioxa-7-aza-spiro[4.5]decane-8-carbonitrile

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 4h; Ambient temperature;
DOI:10.1021/jo00007a025

Reference yield:

: 50606-58-1
N-benzyl-3-piperidinone hydrochloride

: 132462-35-2
7-Benzyl-8-hydroxymethyl-1,4-dioxa-7-aza-spiro[4.5]decane-8-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / p-toluenesulfonic acid / toluene / Heating

2: 1) Hg(OAc)2 / 1) 85 deg C, aq. AcOH, 5 h, 2) 0 deg C, 1 h

3: 1) LiN(iPr)2, HMPA / hexane, THF, -78 deg C

4: NaBH₄ / aq. ethanol / 4 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; mercury(II) diacetate; toluene-4-sulfonic acid; lithium diisopropyl amide; In ethanol; toluene;
DOI:10.1021/jo00007a025

Reference yield:

: 127364-04-9
1-Benzyl-3,3-(ethylenedioxy)piperidine

: 132462-35-2
7-Benzyl-8-hydroxymethyl-1,4-dioxa-7-aza-spiro[4.5]decane-8-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Hg(OAc)2 / 1) 85 deg C, aq. AcOH, 5 h, 2) 0 deg C, 1 h

2: 1) LiN(iPr)2, HMPA / hexane, THF, -78 deg C

3: NaBH₄ / aq. ethanol / 4 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; mercury(II) diacetate; lithium diisopropyl amide; In ethanol;
DOI:10.1021/jo00007a025