1-Benzyl-5,5-(ethylenedioxy)-2-(2-ethoxycarbonyl)-2-piperidinecarbonitrile

Base Information

Chemical Name:1-Benzyl-5,5-(ethylenedioxy)-2-(2-ethoxycarbonyl)-2-piperidinecarbonitrile
CAS No.:132462-34-1
Molecular Formula:C₁₈H₂₂N₂O₄
Molecular Weight:330.384
Hs Code.:

Synonyms:1-Benzyl-5,5-(ethylenedioxy)-2-(2-ethoxycarbonyl)-2-piperidinecarbonitrile

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Chemical Property of 1-Benzyl-5,5-(ethylenedioxy)-2-(2-ethoxycarbonyl)-2-piperidinecarbonitrile

Chemical Property:

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Technology Process of 1-Benzyl-5,5-(ethylenedioxy)-2-(2-ethoxycarbonyl)-2-piperidinecarbonitrile

There total 4 articles about 1-Benzyl-5,5-(ethylenedioxy)-2-(2-ethoxycarbonyl)-2-piperidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50606-58-1
N-benzyl-3-piperidinone hydrochloride

: 132462-34-1
1-Benzyl-5,5-(ethylenedioxy)-2-(2-ethoxycarbonyl)-2-piperidinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / p-toluenesulfonic acid / toluene / Heating

2: 1) Hg(OAc)2 / 1) 85 deg C, aq. AcOH, 5 h, 2) 0 deg C, 1 h

3: 1) LiN(iPr)2, HMPA / hexane, THF, -78 deg C

With N,N,N,N,N,N-hexamethylphosphoric triamide; mercury(II) diacetate; toluene-4-sulfonic acid; lithium diisopropyl amide; In toluene;
DOI:10.1021/jo00007a025

Reference yield:

: 127364-04-9
1-Benzyl-3,3-(ethylenedioxy)piperidine

: 132462-34-1
1-Benzyl-5,5-(ethylenedioxy)-2-(2-ethoxycarbonyl)-2-piperidinecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 1) Hg(OAc)2 / 1) 85 deg C, aq. AcOH, 5 h, 2) 0 deg C, 1 h

2: 1) LiN(iPr)2, HMPA / hexane, THF, -78 deg C

With N,N,N,N,N,N-hexamethylphosphoric triamide; mercury(II) diacetate; lithium diisopropyl amide;
DOI:10.1021/jo00007a025

Reference yield:

: 132462-22-7
1-Benzyl-5,5-(ethylenedioxy)-2-piperidinone

: 132462-34-1
1-Benzyl-5,5-(ethylenedioxy)-2-(2-ethoxycarbonyl)-2-piperidinecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 1) LiAlH₄ / 1) 0 deg C, THF, 1 h, 2) water

2: 1) LiN(iPr)2, HMPA / hexane, THF, -78 deg C

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; lithium diisopropyl amide;
DOI:10.1021/jo00007a025