Technology Process of {4-[(3'-bromophenyl)amino]-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-7-yl}methyl methanesulfonate
There total 10 articles about {4-[(3'-bromophenyl)amino]-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-7-yl}methyl methanesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: AlCl3; N,N-dimethylacetamide / 0.25 h / 20 °C
1.2: 5 h / 20 °C
2.1: 48 percent / aq. NaOCl / 0.5 h / 65 °C
3.1: 54 percent / H2SO4; HNO3 / acetic acid / 0.5 h / 20 °C
4.1: 65 percent / H2 / 10 percent Pd/C / methanol / 24 h / 20 °C
5.1: 63 percent / piperidine / methanol / 4 h / Heating
6.1: 90 percent / POCl3; N,N-dimethylaniline / 2 h / Heating
7.1: 63 percent / conc. HCl / propan-2-ol / 24 h / Heating
8.1: 99 percent / BBr3 / CH2Cl2; hexane / 25 h / -78 - 20 °C
9.1: 60 percent / Et3N / CH2Cl2 / 5 h / 0 - 20 °C
With
piperidine; hydrogenchloride; sodium hypochlorite; aluminium trichloride; N,N-dimethyl acetamide; sulfuric acid; hydrogen; nitric acid; boron tribromide; N,N-dimethyl-aniline; triethylamine; trichlorophosphate;
palladium on activated charcoal;
In
methanol; hexane; dichloromethane; acetic acid; isopropyl alcohol;
1.1: Friedel-Crafts acylation;
DOI:10.1002/ardp.200290003
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 48 percent / aq. NaOCl / 0.5 h / 65 °C
2: 54 percent / H2SO4; HNO3 / acetic acid / 0.5 h / 20 °C
3: 65 percent / H2 / 10 percent Pd/C / methanol / 24 h / 20 °C
4: 63 percent / piperidine / methanol / 4 h / Heating
5: 90 percent / POCl3; N,N-dimethylaniline / 2 h / Heating
6: 63 percent / conc. HCl / propan-2-ol / 24 h / Heating
7: 99 percent / BBr3 / CH2Cl2; hexane / 25 h / -78 - 20 °C
8: 60 percent / Et3N / CH2Cl2 / 5 h / 0 - 20 °C
With
piperidine; hydrogenchloride; sodium hypochlorite; sulfuric acid; hydrogen; nitric acid; boron tribromide; N,N-dimethyl-aniline; triethylamine; trichlorophosphate;
palladium on activated charcoal;
In
methanol; hexane; dichloromethane; acetic acid; isopropyl alcohol;
DOI:10.1002/ardp.200290003
