methyl (E)-3-[2-(4-cyanophenyl)oxazolo[4,5-b]pyridin-6-yl]-2-propenoate

Base Information

Chemical Name:methyl (E)-3-[2-(4-cyanophenyl)oxazolo[4,5-b]pyridin-6-yl]-2-propenoate
CAS No.:364385-31-9
Molecular Formula:C₁₇H₁₁N₃O₃
Molecular Weight:305.293
Hs Code.:

Synonyms:methyl (E)-3-[2-(4-cyanophenyl)oxazolo[4,5-b]pyridin-6-yl]-2-propenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (E)-3-[2-(4-cyanophenyl)oxazolo[4,5-b]pyridin-6-yl]-2-propenoate

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Technology Process of methyl (E)-3-[2-(4-cyanophenyl)oxazolo[4,5-b]pyridin-6-yl]-2-propenoate

There total 4 articles about methyl (E)-3-[2-(4-cyanophenyl)oxazolo[4,5-b]pyridin-6-yl]-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 364385-30-8
4-(6-bromooxazolo[4,5-b]pyridin-2-yl)benzonitrile

: 364385-31-9
methyl (E)-3-[2-(4-cyanophenyl)oxazolo[4,5-b]pyridin-6-yl]-2-propenoate

Guidance literature:: With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; for 24h; Heating;
DOI:10.3987/com-01-9213

Reference yield:

: 21594-52-5
6-bromo-3H-oxazolo[4,5-b]pyridin-2-one

: 364385-31-9
methyl (E)-3-[2-(4-cyanophenyl)oxazolo[4,5-b]pyridin-6-yl]-2-propenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / aq. sodium hydroxide / 8 h / Heating

2: 93 percent / phosphorus pentoxide; hexamethyldisiloxane / 3 h / 200 °C

3: 74 percent / palladium acetate; tri-o-tolylphosphine; triethylamine / dimethylformamide / 24 h / Heating

With phosphorus pentaoxide; sodium hydroxide; Hexamethyldisiloxane; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide;
DOI:10.3987/com-01-9213

Reference yield:

: 60832-72-6
2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one

: 364385-31-9
methyl (E)-3-[2-(4-cyanophenyl)oxazolo[4,5-b]pyridin-6-yl]-2-propenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / Br₂ / dimethylformamide / 2 h / 20 °C

2: 94 percent / aq. sodium hydroxide / 8 h / Heating

3: 93 percent / phosphorus pentoxide; hexamethyldisiloxane / 3 h / 200 °C

4: 74 percent / palladium acetate; tri-o-tolylphosphine; triethylamine / dimethylformamide / 24 h / Heating

With phosphorus pentaoxide; sodium hydroxide; Hexamethyldisiloxane; bromine; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide;
DOI:10.3987/com-01-9213