4-BROMO-2-METHYLBENZENESULFONAMIDE

Base Information

• Chemical Name: 4-BROMO-2-METHYLBENZENESULFONAMIDE
• CAS No.: 116340-67-1
• Molecular Formula: C7H8BrNO2S
• Molecular Weight: 250.116
• Hs Code.: 2935009090
• Mol file: 116340-67-1.mol

Synonyms:4-Bromo-2-methylbenzenesulfonamide;

Chemical Property of 4-BROMO-2-METHYLBENZENESULFONAMIDE

Chemical Property:

• Vapor Pressure: 8.36E-06mmHg at 25°C
• Refractive Index: 1.599
• Boiling Point: 374.423 °C at 760 mmHg
• Flash Point: 180.245 °C
• PSA: 68.54000
• Density: 1.658 g/cm³
• LogP: 3.18600
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-2-methylbenzenesulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-2-METHYLBENZENESULFONAMIDE

There total 6 articles about 4-BROMO-2-METHYLBENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 4-bromo-2-methyl-benzenesulfonamide (116340-67-1)

Guidance literature:

Reference yield: 98.0%

5-bromo-2-toluenesulfonyl chloride (139937-37-4) → 4-bromo-2-methyl-benzenesulfonamide (116340-67-1)

Guidance literature:

With ammonia; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

Reference yield:

meta-bromotoluene (591-17-3) → 4-bromo-2-methyl-benzenesulfonamide (116340-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / chlorosulfonic acid / CHCl₃ / 4 h / 0 °C

2: 78 percent / aq. NH₄OH / dioxane / 6 h / 0 °C

With chlorosulfonic acid; ammonium hydroxide; In 1,4-dioxane; chloroform;

DOI:10.1016/j.bmc.2005.01.039

upstream raw materials:

5-bromo-2-toluenesulfonyl chloride

meta-bromotoluene

4-bromo-2-methythiophenol

Downstream raw materials:

5-bromo-1,1-dioxo-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one

Refernces

• 1、 -. "INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF CANCER". Paragraph 0096. . Retrieved 2020/04/21.
• 2、 -. "NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE". Page/Page column 119. . Retrieved 2016/10/04.