1-(Benzyloxy)-2,2-bis<<(tert-butyldimethylsilyl)oxy>methyl>-3-<(2-methoxyethoxy)methoxy>propane

Base Information

Chemical Name:1-(Benzyloxy)-2,2-bis<<(tert-butyldimethylsilyl)oxy>methyl>-3-<(2-methoxyethoxy)methoxy>propane
CAS No.:156666-21-6
Molecular Formula:C₂₈H₅₄O₆Si₂
Molecular Weight:542.904
Hs Code.:

Synonyms:1-(Benzyloxy)-2,2-bis<<(tert-butyldimethylsilyl)oxy>methyl>-3-<(2-methoxyethoxy)methoxy>propane

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Chemical Property of 1-(Benzyloxy)-2,2-bis<<(tert-butyldimethylsilyl)oxy>methyl>-3-<(2-methoxyethoxy)methoxy>propane

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Technology Process of 1-(Benzyloxy)-2,2-bis<<(tert-butyldimethylsilyl)oxy>methyl>-3-<(2-methoxyethoxy)methoxy>propane

There total 6 articles about 1-(Benzyloxy)-2,2-bis<<(tert-butyldimethylsilyl)oxy>methyl>-3-<(2-methoxyethoxy)methoxy>propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 100-39-0
benzyl bromide

: 156666-20-5
2,2-Bis<<(tert-butyldimethylsilyl)oxy>methyl>-3-<(2-methoxyethoxy)methoxy>-1-propanol

: 156666-21-6
1-(Benzyloxy)-2,2-bis<<(tert-butyldimethylsilyl)oxy>methyl>-3-<(2-methoxyethoxy)methoxy>propane

Guidance literature:: With sodium hydride; In tetrahydrofuran; 1.) 1 h, 2.) reflux, 20 h;
DOI:10.1021/jo00094a044

Reference yield:

: 156666-17-0
2-(Diethoxymethyl)-2-<<(2-methoxyethoxy)methoxy>methyl>-1,3-propanediol

: 156666-21-6
1-(Benzyloxy)-2,2-bis<<(tert-butyldimethylsilyl)oxy>methyl>-3-<(2-methoxyethoxy)methoxy>propane

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 24 h

2: 62 percent / p-TsOH*H₂O / acetone / 0.25 h / Heating

3: 85 percent / NaBH₄ / dioxane / 1 h

4: 70 percent / NaH / tetrahydrofuran / 1.) 1 h, 2.) reflux, 20 h

With 1H-imidazole; sodium tetrahydroborate; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00094a044

Reference yield:

: 156666-15-8
Diethyl (diethoxymethyl)(hydroxymethyl)malonate

: 156666-21-6
1-(Benzyloxy)-2,2-bis<<(tert-butyldimethylsilyl)oxy>methyl>-3-<(2-methoxyethoxy)methoxy>propane

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / diisopropylamine / CH₂Cl₂ / 6 h

2: 83 percent / LiAlH₄ / diethyl ether / 1 h / Ambient temperature

3: imidazole / dimethylformamide / 24 h

4: 62 percent / p-TsOH*H₂O / acetone / 0.25 h / Heating

5: 85 percent / NaBH₄ / dioxane / 1 h

6: 70 percent / NaH / tetrahydrofuran / 1.) 1 h, 2.) reflux, 20 h

With 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium hydride; toluene-4-sulfonic acid; diisopropylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00094a044