944950-33-8

Basic information

• Product Name: 2-(2,3,6-trifluoro-benzylidene)-malonic acid dimethyl ester
• Synonyms: 2-(2,3,6-trifluoro-benzylidene)-malonic acid dimethyl ester
• CAS NO: 944950-33-8
• Molecular Weight: 274.196
• Mol File: 944950-33-8.mol

Chemical Properties

• CAS DataBase Reference: 2-(2,3,6-trifluoro-benzylidene)-malonic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,3,6-trifluoro-benzylidene)-malonic acid dimethyl ester(944950-33-8)
• EPA Substance Registry System: 2-(2,3,6-trifluoro-benzylidene)-malonic acid dimethyl ester(944950-33-8)

Safety Data

• Hazardous Substances Data: 944950-33-8(Hazardous Substances Data)

Upstream product

• 104451-70-9 2,3,6-trifluorobenzaldehyde 
• 108-59-8 malonic acid dimethyl ester 
• 944950-32-7 2-[hydroxy-(2,3,6-trifluoro-phenyl)-methyl]-malonic acid dimethyl ester 

Downstream Products

• 1100362-33-1 C₁₈H₁₃F₅O₄S 
• 1100361-16-7 C₁₉H₁₄F₆O₄S 
• 1420649-45-1 C₁₈H₁₃F₅O₄S 
• 1420649-43-9 C₁₈H₁₄F₄O₄S 
• 1420649-41-7 C₁₈H₁₄BrF₃O₄S 
• 1100361-92-9 C₂₀H₁₈F₄O₅S 
• 1100361-27-0 C₂₁H₁₉F₅O₅S 
• 1100361-34-9 C₂₀H₁₉ClF₂O₅S 

Relevant articles and documents

Design and synthesis of tricyclic sulfones as γ-secretase inhibitors with greatly reduced Notch toxicity

A novel series of tricyclic γ-secretase inhibitors was designed and synthesized via a conformational analysis of literature compounds. The preliminary results have shown that compounds in this new series have much improved in vitro potency and in vivo pro

TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS

Disclosed are novel gamma secretase inhibitors of the formula. Also disclosed are methods of inhibiting gamma-secretase, methods of treating neurodegenerative diseases, and methods of treating Alzheimer's Disease. Also disclosed are processes for preparing alkenes in one reaction step using a mixture of an aldehyde (or ketone) and an alkyl substituted with two electron withdrawing groups, and reacting the mixture with: (a) a sulfonyl halide (e.g., a sulfonyl chloride) and a basic tertiary amine, or, (b) a sulfonyl anhydride and a basic amine, or (c) an aryl-C(O)-halide and a basic tertiary amine, or (d) an aryl-C(O)-O-C(O)-aryl and a basic tertiary amine, or (e) an heteroaryl-C(O)-halide and a basic tertiary amine, or (f) a heteroaryl-C(O)-O-C(O)-heteroaryl and a basic tertiary amine.

BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS

This invention discloses novel gamma secretase inhibitors of the formula: R2 and R3, or R2 and R4, or R3 and R4, together with the atoms to which they are bound, can form a fused cycloalkyl