5-Amino-4-(3-methoxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxylic acid

Base Information

Chemical Name:5-Amino-4-(3-methoxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxylic acid
CAS No.:301847-46-1
Molecular Formula:C₁₅H₁₃N₃O₃S₂
Molecular Weight:347.419
Hs Code.:
DSSTox Substance ID:DTXSID601129653

Synonyms:5-amino-4-(3-methoxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxylic acid;301847-46-1;SCHEMBL4419261;DTXSID601129653;AS-84074;CS-0179798;E82206

Suppliers and Price of 5-Amino-4-(3-methoxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 5-Amino-4-(3-methoxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxylic acid

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:347.03983363
Heavy Atom Count:23
Complexity:442

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC(=C1)C2=C3C(=C(SC3=NC(=N2)SC)C(=O)O)N

Technology Process of 5-Amino-4-(3-methoxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxylic acid

There total 4 articles about 5-Amino-4-(3-methoxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 301846-06-0
ethyl-5-amino-4-(3-methoxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxylate

: 301847-46-1
5-amino-4-(3-methoxyphenyl)-2-methylthio-thieno[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; water; at 50 ℃; for 3h;
DOI:10.1021/jm060247s

Reference yield:

: 128640-73-3
5-carbonitrile-1,6-dihydro-4-(3-methoxyphenyl)-2-(methylthio)-6-oxopyrimidine

: 301847-46-1
5-amino-4-(3-methoxyphenyl)-2-methylthio-thieno[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: POCl₃ / dioxane / 3 h / Heating

2: NaOEt / ethanol / 3 h / 50 °C

3: LiOH / dioxane; H₂O / 3 h / 50 °C

With lithium hydroxide; sodium ethanolate; trichlorophosphate; In 1,4-dioxane; ethanol; water;
DOI:10.1021/jm060247s

Reference yield:

: 128666-82-0
5-carbonitrile-4-chloro-6-(3-methoxyphenyl)-2-(methylthio)pyrimidine

: 301847-46-1
5-amino-4-(3-methoxyphenyl)-2-methylthio-thieno[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: NaOEt / ethanol / 3 h / 50 °C

2: LiOH / dioxane; H₂O / 3 h / 50 °C

With lithium hydroxide; sodium ethanolate; In 1,4-dioxane; ethanol; water;
DOI:10.1021/jm060247s