2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)propionitrile

Base Information

• Chemical Name: 2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)propionitrile
• CAS No.: 952196-29-1
• Molecular Formula: C₂₄H₂₉BrN₂O₅
• Molecular Weight: 505.409

Synonyms:2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)propionitrile

Chemical Property of 2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)propionitrile

Chemical Property:

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Technology Process of 2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)propionitrile

There total 3 articles about 2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

cis-2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)acrylonitrile (952196-28-0) → 2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)propionitrile (952196-29-1)

Guidance literature:

With pyridine; sodium tetrahydroborate; In methanol; for 2h; Heating;

DOI:10.1021/jo071038y

Reference yield:

2-bromo-4,5-dimethoxybenzaldehyde (5392-10-9) → 2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)propionitrile (952196-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / NaOEt / ethanol / 70 °C

2: 84 percent / NaBH₄; pyridine / methanol / 2 h / Heating

With pyridine; sodium tetrahydroborate; sodium ethanolate; In methanol; ethanol;

DOI:10.1021/jo071038y

Reference yield:

N-methyl-N-(2-cyanomethyl-4,5-dimethoxyphenethyl)acetamide (52590-27-9) → 2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)propionitrile (952196-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / NaOEt / ethanol / 70 °C

2: 84 percent / NaBH₄; pyridine / methanol / 2 h / Heating

With pyridine; sodium tetrahydroborate; sodium ethanolate; In methanol; ethanol;

DOI:10.1021/jo071038y

upstream raw materials:

cis-2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)acrylonitrile

2-bromo-4,5-dimethoxybenzaldehyde

N-methyl-N-(2-cyanomethyl-4,5-dimethoxyphenethyl)acetamide

Downstream raw materials:

2-{2-[2-(N-acetyl-N-methylamino)ethyl]-4,5-dimethoxyphenyl}-3-(2-bromo-4,5-dimethoxyphenyl)propionic acid

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